PMID: 7086662Apr 1, 1982Paper

1,4-Bis(4-guanylphenylethyl)benzenes as potential antitrypanosomal agents

Journal of Pharmaceutical Sciences
B P DasDavid W Boykin

Abstract

A series of 1,4-bis(4-guanylphenylethyl)benzenes, including masked amidines in which the guanyl function is incorporated into a heterocyclic ring, were prepared for screening as potential antitrypanosomal agents. Some of these compounds were active against Trypanosoma rhodesiense in mice. The diamidines were prepared by standard methods from 1,4-bis(4-cyanophenylethyl)benzene which was obtained from 1,4-bis(4-cyanostyryl)benzene by diimide reduction. The latter compound was prepared by the Wittig reaction between 4-cyanobenzylphosphonium ylide and terephthaldicarboxaldehyde.

References

Apr 1, 1977·Journal of Medicinal Chemistry·B P Das, David W Boykin

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