PMID: 26320511Sep 1, 2015Paper

14-bp Insertion/Deletion Polymorphism of the HLA-G gene in Breast Cancer among Women from North Western Iran

Asian Pacific Journal of Cancer Prevention : APJCP
Mehdi HaghiAbbas Sahebghadam Lotfi

Abstract

The human leukocyte antigen-G (HLA-G) gene is highly expressed in cancer pathologies and is one strategy used by tumor cells to escape immune surveillance. A 14-bp insertion/deletion (InDel) polymorphism of the HLA-G gene has been suggested to be associated with HLA-G mRNA stability and the expression of HLA-G. The aim of present study was to assess any genetic association between this polymorphism and breast cancer among Iranian-Azeri women. In this study 227 women affected with breast cancer, in addition to 255 age-sex and ethnically matched healthy individuals as the control group, participated. Genotyping was performed using polymerase chain reaction and electrophoresis assays. The data were compiled according to the genotype and allele frequencies, compared using the Chi-square test. Statistical significance was set at P<0.05. In this case-control study, no significant difference was found between the case and control groups at allelic and genotype levels, although there is a slightly higher allele frequency of HLA-G 14bp deletion in breast cancer affected group. However,when the stage I subgroup was compared with stage II plus stage III subgroup of affected breast cancer, a significant difference was seen with the 14 bp d...Continue Reading

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Citations

Apr 25, 2019·International Journal of Molecular Sciences·Franziska M WürfelWolfgang Würfel
Dec 5, 2019·Journal of Clinical Pathology·Sony KadiamJayalakshmi Mariakuttikan
Jul 10, 2019·Journal of Translational Medicine·Meysam Moghbeli
Nov 2, 2019·Biomarkers in Medicine·Xiaofeng DaiPeihua Lu

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