Abstract
To determine the association of 1,5-anhydroglucitol (1,5-AG) with neonatal birth weight (NBW) and neonatal hypoglycemia (+NH) in pregnancies complicated by diabetes. We assessed a retrospective cohort of 102 females, 17 with gestational diabetes (GDM), 48 with type 1 diabetes mellitus (T1DM), and 37 with type 2 diabetes mellitus (T2DM). 1,5-AG and glycated hemoglobin A1C (A1C) values throughout pregnancy were extracted. Linear regression was used to assess their association with NBWs z-scores adjusting for maternal age, ethnicity and body mass index (BMI). +NH was defined by a note in the infant record, glucose <1.7 mmol/L in the first 24 h, or <2.5 mmol/L in the first 48 h after birth. A t test or Welch's approximate t test was used to compare the mean 1,5-AG and A1C of mothers with +NH versus those without (-NH), adjusted for gestational age and analyzed by diabetes type and across trimesters. Mean 1,5-AG significantly differed across groups: T1DM 3.77 ± 2.82 μg/mL, T2DM 5.73 ± 4.38 μg/mL, GDM 8.89 ± 4.39 μg/mL (P<.0001), suggesting less glucose exposure in GDM relative to T1DM or T2DM. A negative linear association was found between mean 1,5-AG and z-scores (R= -0.28, P = .005. In contrast, the association between mean A1C a...Continue Reading
References
Dec 1, 1991·Diabetes·B E Metzger
Jan 1, 1990·Acta Obstetricia Et Gynecologica Scandinavica·M TetsuoT Matsunaga
Dec 1, 1982·American Journal of Obstetrics and Gynecology·M W Carpenter, D R Coustan
Nov 9, 1995·The New England Journal of Medicine·M de VecianaA T Evans
Oct 1, 1994·Diabetes Research and Clinical Practice·T Yamanouchi, Y Akanuma
Jan 1, 1994·Annual Review of Medicine·T A Buchanan, J L Kitzmiller
Apr 8, 1998·Archives of Pediatrics & Adolescent Medicine·L CorderoS G Gabbe
Sep 10, 1998·American Journal of Obstetrics and Gynecology·T S NesbittB Herrchen
May 22, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J ErikssonD Barker
Aug 3, 2001·Pediatrics·M S KramerUNKNOWN Fetal/Infant Health Study Group of the Canadian Perinatal Surveillance System
Jun 28, 2003·Diabetes Technology & Therapeutics·John B BuseJanet B McGill
Mar 2, 2005·Obstetrics and Gynecology·UNKNOWN ACOG Committee on Practice Bulletins
Aug 16, 2005·Diabetes Research and Clinical Practice·Sebastian KuczyńskiMarzena Dworacka
Nov 9, 2005·Disease Markers·Marzena Dworacka, Hanna Winiarska
Dec 13, 2005·Diabetologia·A KerssenG H A Visser
Mar 1, 2006·American Journal of Perinatology·Arie L AlkalayCharles F Simmons
May 30, 2006·Diabetes Care·Kathleen M DunganSteven Wittlin
Jul 5, 2008·Diabetes Care·Kunihiko HashimotoMasafumi Koga
Oct 6, 2010·Diabetes Care·Lois JovanovicDavid J Pettitt
Mar 2, 2011·Pediatrics·David H Adamkin, David H Adamkin
May 6, 2011·Diabetes Care·Jeroen HermanidesJ Hans DeVries
Jun 28, 2011·Diabetes Care·Judith C KuenenUNKNOWN ADAG Study Group
Nov 9, 2011·Pediatric Diabetes·Sanjeev N MehtaLori Mb Laffel
Jan 3, 2012·Diabetes Care·Hilary K SeligmanAlicia Fernandez
Feb 4, 2012·Diabetes Care·Lynn P LoweUNKNOWN HAPO Study Cooperative Research Group
May 12, 2012·Endocrine Reviews·Charles L Brooks
Jan 4, 2013·Diabetes Care·UNKNOWN American Diabetes Association
Jan 26, 2013·Diabetes Care·Anna L SecherElisabeth R Mathiesen
Feb 5, 2013·Diabetologia·N NowakM T Malecki
Jan 25, 2014·Diabetes Care·Adam M Deane, Michael Horowitz
Nov 5, 2014·Diabetes Care·Michael J A MareshUNKNOWN Diabetes and Pre-eclampsia Intervention Trial Study Group
Citations
May 26, 2017·Diabetes Technology & Therapeutics·Lorena Alarcon-Casas Wright, Irl B Hirsch
Nov 30, 2016·Acta Diabetologica·Yao WangZilin Sun
Oct 15, 2019·Journal of the Endocrine Society·John Jack L LeahyWilliam H Polonsky
Aug 23, 2019·Endocrine·Enav YefetZohar Nachum
Sep 12, 2018·International Journal of Molecular Sciences·Kathleen O'NeillSara E Pinney
Aug 16, 2018·Frontiers in Endocrinology·Sofia NahavandiElif I Ekinci
Aug 15, 2020·Frontiers in Immunology·Flaminia BardanzelluVassilios Fanos
Dec 20, 2019·Obstetric Medicine·Jessica Gehlert, Adam Morton
Jan 27, 2021·Diabetes Care·Claire L MeekUNKNOWN CONCEPTT Collaborative Group
Jun 3, 2021·International Journal of Molecular Sciences·Simon AlesiAya Mousa
May 21, 2021·Medicine·Yun Xu, Yingying Yu