1,5-ANHYDROGLUCITOL AND NEONATAL COMPLICATIONS IN PREGNANCY COMPLICATED BY DIABETES.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Lorena A WrightZane Brown

Abstract

To determine the association of 1,5-anhydroglucitol (1,5-AG) with neonatal birth weight (NBW) and neonatal hypoglycemia (+NH) in pregnancies complicated by diabetes. We assessed a retrospective cohort of 102 females, 17 with gestational diabetes (GDM), 48 with type 1 diabetes mellitus (T1DM), and 37 with type 2 diabetes mellitus (T2DM). 1,5-AG and glycated hemoglobin A1C (A1C) values throughout pregnancy were extracted. Linear regression was used to assess their association with NBWs z-scores adjusting for maternal age, ethnicity and body mass index (BMI). +NH was defined by a note in the infant record, glucose <1.7 mmol/L in the first 24 h, or <2.5 mmol/L in the first 48 h after birth. A t test or Welch's approximate t test was used to compare the mean 1,5-AG and A1C of mothers with +NH versus those without (-NH), adjusted for gestational age and analyzed by diabetes type and across trimesters. Mean 1,5-AG significantly differed across groups: T1DM 3.77 ± 2.82 μg/mL, T2DM 5.73 ± 4.38 μg/mL, GDM 8.89 ± 4.39 μg/mL (P<.0001), suggesting less glucose exposure in GDM relative to T1DM or T2DM. A negative linear association was found between mean 1,5-AG and z-scores (R= -0.28, P = .005. In contrast, the association between mean A1C a...Continue Reading

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Citations

May 26, 2017·Diabetes Technology & Therapeutics·Lorena Alarcon-Casas Wright, Irl B Hirsch
Oct 15, 2019·Journal of the Endocrine Society·John Jack L LeahyWilliam H Polonsky
Sep 12, 2018·International Journal of Molecular Sciences·Kathleen O'NeillSara E Pinney
Aug 16, 2018·Frontiers in Endocrinology·Sofia NahavandiElif I Ekinci
Aug 15, 2020·Frontiers in Immunology·Flaminia BardanzelluVassilios Fanos
Jan 27, 2021·Diabetes Care·Claire L MeekUNKNOWN CONCEPTT Collaborative Group
Jun 3, 2021·International Journal of Molecular Sciences·Simon AlesiAya Mousa

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