PMID: 8596377Mar 9, 1996Paper

15-year follow-up of renin and blood pressure in reflux nephropathy

Lancet
C D GoonasekeraM J Dillon

Abstract

Beginning in 1978 a cohort of patients with reflux nephropathy first seen at a London Childrens hospital have had 5-yearly follow-ups. This is the fourth (15-year) report from that series. Of the original 100 normotensive children with reflux nephropathy 78 were traced for the 15-year study in 1994. Five patients were excluded because of nephrectomy, ten for other reasons, and eight refused to take part, leaving 55. 26 were on oral contraceptives. Supine blood pressure and plasma renin activity (PRA) were measured, and daily sodium excretion was assessed on a sample of overnight urine. Of the 55 patients (15 male, 40 female, median age 27 years, range 20-31), five had systolic and two had diastolic hypertension. Compared with the 10-year (1988) follow-up there was no change in blood pressure standard deviation scores (SDS) in this cohort. PRA showed an increasing dissociation from controls after 15 years of age and was significantly above that of controls by age 25. Exclusion of the patients on oral contraceptives did not significantly alter the results. The PRA values in 1988 were not individually predictive of the development of hypertension over the ensuing 5 years. Previously, in the long-term study of reflux nephropathy, b...Continue Reading

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Citations

Aug 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Stephen D MarksKjell Tullus
Apr 19, 2008·Current Urology Reports·Sherry Sedberry-Ross, Hans G Pohl
Feb 16, 2005·The Journal of Urology·Scott B FarnhamJohn C Pope
Nov 21, 2007·Current Opinion in Pediatrics·Ron Keren
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·K KassirA Arrieta
Mar 23, 2013·Disease Models & Mechanisms·Samantha E BowenSoman N Abraham
Dec 17, 2005·Paediatric Drugs·Gaurang Shah, Jyoti Upadhyay
Mar 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Heather J LambertUNKNOWN UK VUR Study Group
Jan 24, 2012·European Urology·Jonathan C RouthDuncan T Wilcox
Sep 8, 2011·Advances in Chronic Kidney Disease·Tej K Mattoo
Nov 26, 2010·The Medical Clinics of North America·Ardavan Akhavan, Jeffrey A Stock
Sep 9, 2008·Journal of Pediatric Urology·Marc Cendron
Nov 16, 2006·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Takeshi AsanoOsamu Fujino
Feb 14, 2003·The Journal of Pediatrics·Ludwig PatzerJoachim Misselwitz
Sep 25, 2012·The Journal of Urology·Yong Seung LeeSang Won Han
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Gabrielle WilliamsJonathan C Craig
Jun 6, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tuija Lahdes-VasamaKai Rönnholm
Apr 25, 2000·Journal of Hypertension·M WennerströmU Jodal
Aug 1, 1997·Journal of Hypertension·C D GoonasekeraM J Dillon
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·K L LiawJ F Fraumeni
Dec 10, 1999·Acta Paediatrica. Supplement·S H JacobsonB Jakobsson
Apr 18, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kuang-Yen LinYuan-Yow Chiou
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Giuliana LamaMaria Esposito-Salsano

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