15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception

Life Sciences
J T Clemente-NapimogaMarcelo H Napimoga

Abstract

To verify whether the nanoencapsulation of 15d-PGJ(2) in poly(D,L-lactide-co-glycolide) (PLGA) nanocapsules (15d-PGJ(2)-NC) might potentialize its antinociceptive activity into rats' temporomandibular joint (TMJ). Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used to evaluate the morphology and suspension of the PLGA nanocapsules. Rats were pretreated (15 min) with an intra-TMJ injection of unloaded 15d-PGJ(2) or 15d-PGJ(2)-NC at concentrations of 10, 100 or 1000 pg followed by an ipsilateral intra-TMJ injection of 1.5% formalin. The nociceptive behavioral response was observed during 45 min; animals were then sacrificed and the periarticular tissue was removed for IL-1β measurements. TEM and AFM analyses showed that 15d-PGJ(2)-NC is spherical without any aggregates or adhesion confirming that this formulation is a good drug carrier system for 15d-PGJ(2). Pretreatment with 15d-PGJ(2)-NC (100 and 1000 pg/TMJ), but not unloaded 15d-PGJ(2), was found to significantly decrease the release of IL-1β cytokine and the animals' nociceptive behavioral response induced by intra-TMJ injection of formalin. The compound 15d-PGJ(2)-NC might be used as a potential antinociceptive and anti-inflammatory agent to t...Continue Reading

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Citations

Apr 20, 2013·International Immunopharmacology·Marcelo Henrique NapimogaElizabeth Ferreira Martinez
Jun 4, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C G MacedoJ T Clemente-Napimoga
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May 23, 2018·Journal of Tissue Engineering·Khandmaa DashnyamHae-Won Kim
May 7, 2019·Molecular Medicine Reports·Marcelo H NapimogaDaniele R de Araújo
May 11, 2020·International Immunopharmacology·Henrique Ballassini AbdallaJuliana Trindade Clemente Napimoga
Dec 31, 2019·Neuroscience·Graciana de AzambujaMaria Cláudia Gonçalves de Oliveira-Fusaro
Oct 23, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Qinfeng DingKaili Lin
Aug 18, 2021·Journal of Stomatology, Oral and Maxillofacial Surgery·Florent BarryRomain Nicot

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