16, 16 dimethyl prostaglandin E2 reduces histamine release from the stomach and protects the gastric mucosal barrier altered by ethanol in neutral solution

B D Soper, B L Tepperman


Damage to the gastric mucosal barrier results in histamine release from intramucosal stores. Previous reports have shown that 16, 16 dimethyl prostaglandin E2 (dm PGE2) protects the stomach from injury by various damaging agents in either acidic or neutral solution. Furthermore histamine released in response to a damaging drug in an acidic medium was reduced by dm PGE2. Using the Heidenhain pouch dog preparation, the present study examined the action of dm PGE2 on ethanol-induced barrier breaking and histamine release in neutral solution. Topical ethanol treatment (15% w/v) damaged the gastric mucosal barrier as evidenced by increased net fluxes of Na+ and K+ and an increase in the histamine content of the fluid irrigating the histamine content of the fluid irrigating the Heidenhain pouch. Intravenous injection of dm PGE2 in the doses of 0.01, 0.10 and 1.00 microgram/kg one-half hour before ethanol administration significantly reduced the appearance of Na+, K+ and histamine. It is concluded that dm PGE2 effectively protects the canine gastric mucosa from damaging agents in neutral solution as evidenced by a reduction in the luminal appearance of Na+, K+ and histamine.


Feb 1, 1976·The American Journal of Digestive Diseases·V P DinosoN S Murthy
Feb 1, 1972·Prostaglandins·P AlbroL Fishbein
Feb 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·L R Johnson
Dec 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport
Nov 10, 1958·The Journal of Physiology·R A GREGORY


Apr 1, 1982·Digestive Diseases and Sciences·D AuresM I Grossman
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·D W Hall, W E van den Hoven

Related Concepts

Canis familiaris
Structure of Pyloric Gland
Histamine Release
Hydrogen-Ion Concentration
Prostaglandins E, Synthetic
Secretory Rate
16,16-Dimethylprostaglandin E2

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