16,16-Dimethyl prostaglandin E2 induces villus contraction in rats without affecting intestinal restitution

Gastroenterology
R A EricksonJ Stachura

Abstract

In a previous study we found that 16,16-dimethyl prostaglandin E2 protects the small intestine against chenodeoxycholic acid injury in the rat. One possible explanation for prostaglandin's protective action may be that prostaglandin-induced villus contraction accelerates mucosal restitution. This hypothesis was tested in rats by perfusing intestinal segments in vivo in a single-pass fashion with 0.125-0.5 micrograms/L of 16,16-dimethyl prostaglandin E2. These studies showed a dose-dependent, reversible contraction of intestinal villi and crypts. To test the effect of this contraction on mucosal restitution, standardized intestinal injury was produced in indomethacin-pretreated rats perfused in vivo with 5 mmol/L chenodeoxycholic acid. The rats were then perfused with bile acid-free buffer containing either 0.5 microgram/mL of 16,16-dimethyl prostaglandin E2 or vehicle. This study showed that despite decreasing villus height after bile acid injury, 16,16-dimethyl prostaglandin E2 did not significantly affect the rate of morphologic (assessed by villus denudation) or functional (assessed by mannitol and water absorption) restitution of the injured intestinal mucosa. Thus, although 16,16-dimethyl prostaglandin E2 causes villus con...Continue Reading

Citations

Jun 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jody L GookinRobert A Argenzio
Apr 13, 2007·Physiological Reviews·Anthony T BlikslagerJack Odle
Dec 19, 2014·Journal of Veterinary Emergency and Critical Care·Vanessa L Cook, Anthony T Blikslager
Nov 17, 2017·Annual Review of Animal Biosciences·Anthony Blikslager, Liara Gonzalez
Aug 9, 2003·Critical Care Medicine·Joshua M V Mammen, Jeffrey B Matthews
Feb 24, 2001·Equine Veterinary Journal. Supplement·N B Campbell, A T Blikslager
Apr 11, 2003·Journal of the American Veterinary Medical Association·Julia Tomlinson, Anthony Blikslager
Aug 4, 2011·Equine Veterinary Journal. Supplement·J F Marshall, A T Blikslager
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Dianne LittleAnthony T Blikslager
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jody L GookinRobert A Argenzio
Jan 14, 1999·The American Journal of Physiology·A T BlikslagerR A Argenzio
Feb 9, 2002·The Journal of Nutritional Biochemistry·Derek J. Ruthig, Kelly A. Meckling-Gill

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.