16S gut community of the Cameron County Hispanic Cohort

Microbiome
Matthew C RossJoseph F Petrosino

Abstract

Obesity and type 2 diabetes (T2D) are major public health concerns worldwide, and their prevalence has only increased in recent years. Mexican Americans are disproportionately afflicted by obesity and T2D, and rates are even higher in the United States-Mexico border region. To determine the factors associated with the increased risk of T2D, obesity, and other diseases in this population, the Cameron County Hispanic Cohort was established in 2004. In this study, we characterized the 16S gut community of a subset of 63 subjects from this unique cohort. We found that these communities, when compared to Human Microbiome Project subjects, exhibit community shifts often observed in obese and T2D individuals in published studies. We also examined microbial network relationships between operational taxonomic units (OTUs) in the Cameron County Hispanic Cohort (CCHC) and three additional datasets. We identified a group of seven genera that form a tightly interconnected network present in all four tested datasets, dominated by butyrate producers, which are often increased in obese individuals while being depleted in T2D patients. Through a combination of increased disease prevalence and relatively high gut microbial homogeneity in the sub...Continue Reading

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Citations

Feb 13, 2016·Frontiers in Microbiology·Belén CarbonettoMartin P Vazquez
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Jun 1, 2020·Medicine in Microecology·Xu-Wen Wang, Yang-Yu Liu

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Datasets Mentioned

BETA
SRP053023

Software Mentioned

SparCC
ref
uclust

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