PMID: 11606022Oct 19, 2001Paper

17-beta-estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A

International Immunopharmacology
J K JenkinsR W McMurray

Abstract

In this investigation, the effects and potential mechanisms of female sex steroid action on proliferation, cell cycling, and apoptosis in Jurkat CD4 + T lymphocytes were examined. 17-beta-Estradiol (estrogen) inhibited Jurkat T cell proliferation, stimulated accumulation of cells in S and G2/M phases of the cell cycle, and induced apoptosis over 72 h in a dose-dependent manner. 4-Pregnene-3,20-dione (progesterone) did not induce redistribution of the cells in the cell cycle but did induce cytostasis and slightly increased apoptosis. Simultaneous staining with anti-BrDU and propidium iodide indicated that estrogen-treated Jurkat T cells proceeded through S phase prior to apoptosis. Progesterone halted cell cycle progression; cells did not progress through S phase or incorporate BrDU. Both hormones decreased the percentage of cells in S or G2/M expressing cyclin A protein, but did not affect cyclin D protein expression. Cyclin A mRNA was markedly decreased by estrogen. Bcl-2 protein and mRNA were also reduced in estrogen but not progesterone-treated Jurkat T lymphocytes. This data shows that high concentrations of estrogen or progesterone significantly suppress lymphoproliferation in association with suppression of cyclin A. Addi...Continue Reading

References

Nov 1, 1979·Arthritis and Rheumatism·J RoubinianJ A Sadakian
Sep 1, 1992·Cancer Metastasis Reviews·M P TenniswoodJ E Welsh
Jan 1, 1992·Annual Review of Immunology·J J CohenK S Sellins
Mar 1, 1991·Biochemical Pharmacology·M M ChaudoreilleA Crevat
Jan 1, 1989·Annual Review of Physiology·C Rories, T C Spelsberg
Feb 10, 1989·Cell·M Beato
Mar 1, 1985·European Journal of Immunology·U LandegrenH Wigzell
Feb 2, 1995·Nature·J DheinP H Krammer
Jun 12, 1995·Annals of the New York Academy of Sciences·D P McDonnellR B Stein
Jun 1, 1995·Journal of Cellular Biochemistry·W Meikrantz, R Schlegel
Jun 1, 1995·Journal of Cellular Biochemistry·K L King, J A Cidlowski
Jan 1, 1994·Annual Review of Biochemistry·M J Tsai, B W O'Malley
Feb 1, 1994·Immunological Reviews·P W KincadeG Smithson
Mar 1, 1993·Clinical Immunology and Immunopathology·B H AthreyaW V Williams
Jan 30, 1994·Cancer Letters·M V Blagosklonny, L M Neckers
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoE Hamel
Dec 1, 1995·Current Opinion in Cell Biology·G I EvanE Harrington
Feb 1, 1997·Rheumatic Diseases Clinics of North America·M A KhamashtaG R Hughes
Feb 1, 1997·Rheumatic Diseases Clinics of North America·J L Nelson, M Ostensen
Mar 20, 1999·Science·C C WhitacreP A O'Looney
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·M S BynoeB Diamond

❮ Previous
Next ❯

Citations

Dec 1, 2006·Histochemistry and Cell Biology·Thomas SchmidtMichel Le Hir
Aug 13, 2011·Clinical Rheumatology·Maryam RastinMahmoud Mahmoudi
Oct 19, 2013·Bulletin of Experimental Biology and Medicine·A M ScherbakovN E Kushlinskii
Mar 2, 2010·Cancer Biotherapy & Radiopharmaceuticals·Dandan HuangJianyong Wu
May 19, 2006·International Journal of Environmental Research and Public Health·Hari H P CohlyMichael F Angel
Jul 14, 2010·International Journal of Environmental Research and Public Health·Kenneth NdebelePaul B Tchounwou
Aug 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yan LiGuangmei Yan
Jul 19, 2005·Life Sciences·Genhong YaoYayi Hou
Oct 6, 2007·Journal of Environmental Sciences (China)·Da-qiang YinAi-qian Zhang
Jun 10, 2010·Clinical and Experimental Immunology·W-U KimC-S Cho
Jan 10, 2013·Neurobiology of Aging·Elaine DelvauxPaul D Coleman
Dec 21, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lesley K ShelleyChristopher J Kennedy
Feb 27, 2007·International Immunopharmacology·Genhong YaoPeiyuan Zhu
May 11, 2010·Metal Ions in Biology and Medicine : Proceedings of the ... International Symposium on Metal Ions in Biology and Medicine Held ... = Les Ions Métalliques En Biologie Et En Médecine : ... Symposium International Sur Les Ions Métalliques En Biologie Et En M·Alice M WalkerPaul B Tchounwou
Feb 24, 2010·Toxicology and Industrial Health·Shuiqing QiuWeiyun Zhang
May 6, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Minyue DongHefeng Huang
Mar 10, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Batchu Hareramadas, Umesh Rai
Dec 30, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Suzue HiranoToshiaki Hanafusa
Dec 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela MaselliWalter Malorni
Jun 9, 2016·Tissue Engineering and Regenerative Medicine·Yoon Young KimSung Joon Kim
Oct 20, 2018·Frontiers in Immunology·Vaishali R Moulton
Sep 30, 2008·Arquivos brasileiros de endocrinologia e metabologia·Mardelene G GomesRogéria Serakides

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis