17-beta Estradiol attenuates streptozotocin-induced diabetes and regulates the expression of renal sodium transporters

Kidney International
Shahla RiaziCarolyn M Ecelbarger

Abstract

Diabetes mellitus is associated with natriuresis, whereas estrogen has been shown to be renoprotective in diabetic nephropathy and may independently regulate renal sodium reabsorption. The aim of this study was to determine the effects of 17-beta estradiol (E(2)) replacement to diabetic, ovariectomized (OVX) female rats on the expression of major renal sodium transporters. Female, Sprague-Dawley rats (210 g) were randomized into four groups: (1) OVX; (2) OVX+E(2); (3) diabetic+ovariectomized (D+OVX); and (4) diabetic+ovariectomized+estrogen (D+OVX+E(2)). Diabetes was induced by a single intraperitoneal injection of streptozotocin (55 mg/kg.body weight (bw)). Rats received phytoestrogen-free diet and water ad libitum for 12 weeks. E(2) attenuated hyperglycemia, hyperalbuminuria, and hyperaldosteronism in D rats, as well as the diabetes-induced changes in renal protein abundances for the bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2), and the alpha- and beta-subunits of the epithelial sodium channel (ENaC), that is, E(2) decreased NKCC2, but increased alpha- and beta-ENaC abundances. In nondiabetic rats, E(2) decreased plasma K(+) and increased urine K(+)/Na(+) ratio, as well as decreased the abundance of NKCC2, beta-ENaC, a...Continue Reading

References

Nov 1, 1996·Clinical Endocrinology·K E StamatakiG P Piaditis
Oct 8, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A NadalB Soria
Oct 8, 1999·The Journal of Clinical Investigation·S MasilamaniM A Knepper
Jul 15, 2000·American Journal of Physiology. Renal Physiology·C A EcelbargerM A Knepper
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Carolyn A EcelbargerJoseph G Verbalis
Jul 27, 2001·Diabetes·J S DormanUNKNOWN Familial Autoimmune and Diabetes (FAD) Study
Sep 28, 2001·Experimental Neurology·C A EcelbargerM A Knepper
Mar 23, 2002·Journal of Hypertension·Miriam Alvarez-Guerra, Ricardo P Garay
May 25, 2002·Kidney International·Crystal A BickelCarolyn A Ecelbarger
Apr 17, 2003·American Journal of Physiology. Renal Physiology·Dongun KimJanet D Klein
Aug 9, 2003·American Journal of Physiology. Renal Physiology·Jian SongCarolyn A Ecelbarger
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Marie-Luise GrossEberhard Ritz
Jul 1, 2004·American Journal of Physiology. Renal Physiology·Jian SongCarolyn A Ecelbarger
Aug 12, 2004·American Journal of Physiology. Renal Physiology·Jian SongCarolyn A Ecelbarger
Sep 30, 2004·American Journal of Physiology. Renal Physiology·Richard W MankheyChristine Maric
Dec 25, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Balazs AntusUwe Heemann
Feb 3, 2005·American Journal of Physiology. Renal Physiology·Giovambattista CapassoGiuseppe Bianchi

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Citations

Mar 12, 2009·Pflügers Archiv : European journal of physiology·Johannes Loffing, Christoph Korbmacher
May 5, 2006·Current Hypertension Reports·Carolyn A Ecelbarger, Swasti Tiwari
Nov 5, 2010·American Journal of Physiology. Renal Physiology·Maggie K Diamond-StanicHeddwen L Brooks
Jun 8, 2006·American Journal of Nephrology·Shahla RiaziCarolyn A Ecelbarger
Feb 3, 2007·Kidney & Blood Pressure Research·Barry B McGuireNeil G Docherty
Jun 7, 2012·Climacteric : the Journal of the International Menopause Society·N J HeoJ S Han
May 5, 2017·American Journal of Physiology. Renal Physiology·Eman Y GoharDavid M Pollock
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Swasti TiwariCarolyn A Ecelbarger
Aug 5, 2017·Journal of the American Society of Nephrology : JASN·Luciana C VeirasAlicia A McDonough
Sep 23, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jennifer L RogersSusan E Mulroney
Mar 29, 2007·American Journal of Physiology. Renal Physiology·Maggie KeckHeddwen L Brooks
Aug 10, 2007·American Journal of Physiology. Renal Physiology·Swasti TiwariCarolyn A Ecelbarger
Oct 8, 2013·American Journal of Physiology. Lung Cellular and Molecular Physiology·Megan M GreenleeDouglas C Eaton
May 30, 2014·Physiological Reports·Yamil R YusefBrian J Harvey
Jul 28, 2018·Frontiers in Physiology·Stine Julie TingskovRikke Nørregaard
Apr 19, 2018·American Journal of Physiology. Renal Physiology·Debra L IrsikPascale H Lane
Aug 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tengis S PavlovAlexander Staruschenko
Jan 15, 2016·American Journal of Physiology. Renal Physiology·Anita T LaytonAurélie Edwards
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du
Mar 14, 2012·Steroids·Vinciane Saint-CriqBrian J Harvey
Jul 3, 2021·Pharmaceuticals·Mohamed M El-KadyMaha Saber-Ayad
Dec 2, 2020·Current Drug Metabolism·Sangita Maiti DuttaSmarajit Maiti

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