17 beta-Estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias after brief ischemia/reperfusion

Circulation
Y D KimD E Lees

Abstract

Brief myocardial ischemia is associated with myocardial and coronary endothelial dysfunction caused by oxygen free radicals released during reperfusion. Estrogen, known to have antioxidant activity, may prevent these complications. We assessed the effect of 2 weeks of treatment with 17 beta-estradiol (E, 100 micrograms.kg-1.d-1, n = 12) or placebo (P, n = 15) on myocardial and coronary endothelial function during the first 2 hours of reperfusion in dogs subjected to 15 minutes of ischemia induced by occlusion of the left anterior descending coronary artery (LAD). Our results show that the incidence of ventricular arrhythmias significantly decreased in E (3 of 12) compared with P (11 of 15). Systolic shortening, significantly depressed in P during early reperfusion, was maintained at preischemic levels in E. During reperfusion, the increase in LAD flow to acetylcholine, attenuated in P (60 +/- 6%), was preserved in E endothelium. (151 +/- 28%) and was associated with increased serum nitrite/nitrate concentration. n-Pentane in exhaled gas in vivo, an index of lipid peroxidation, increased significantly during early reperfusion in P (from 9.1 +/- 1.9 to 41.6 +/- 13.0 ppb, P < .05) but not in E (23.0 +/- 6.9 ppb). In vitro, arteria...Continue Reading

References

Jan 1, 1975·The Journal of Clinical Endocrinology and Metabolism·H JurjensM G Woldring
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J F WangH de Groot
Dec 15, 1992·Annals of Internal Medicine·D GradyS R Cummings
Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
Sep 12, 1991·The New England Journal of Medicine·M J StampferC H Hennekens
Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Jan 1, 1988·Free Radical Biology & Medicine·G M Rubanyi
Jan 1, 1984·Methods in Enzymology·R B Johnston
Mar 10, 1994·The American Journal of Cardiology·M O JeroudiR Bolli
Jan 27, 1994·The American Journal of Cardiology·R Burges, D Moisey
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·A M Lefer, D J Lefer
Jun 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·A D Mooradian

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Citations

Feb 2, 2006·Basic Research in Cardiology·S TurcatoA J Baker
Aug 17, 2006·Cardiovascular Drugs and Therapy·Eftihia SbarouniDimitrios Th Kremastinos
Aug 7, 2008·Cardiovascular Toxicology·Erin A Booth, Benedict R Lucchesi
Apr 28, 2005·Free Radical Biology & Medicine·Scott W Ballinger
Apr 23, 2003·European Journal of Pharmacology·Eftihia SbarouniDimitrios Th Kremastinos
Apr 5, 2003·Journal of Molecular and Cellular Cardiology·K SugishitaW H Barry
Aug 29, 2002·Journal of Cardiovascular Pharmacology·Stephanie BeerStefan Neubauer
Sep 18, 2002·Kidney International·Veronika MüllerAttila J Szabó
Feb 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yan WangHenan Zhao
Jan 21, 2016·Journal of Cardiovascular Translational Research·Sivaporn SivasinprasasnNipon Chattipakorn
Mar 2, 2016·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Padmini EkambaramChristina Joseph Mary Susai
May 24, 2008·The Annals of Thoracic Surgery·Howard K SongRoss M Ungerleider
Mar 20, 2003·European Journal of Heart Failure·Gerasimos Filippatos, John T Parissis
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·George I Gorodeski
May 24, 2005·International Journal of Cardiology·Tsung-Ming LeeChang-Her Tsai
Apr 14, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P ChiariV Piriou
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Gregory S CherrRandolph L Geary
Apr 13, 2004·The Veterinary Record·C A WyseS Love
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Mikhail A SovershaevKirsti Ytrehus
Jun 25, 1998·The American Journal of Physiology·A A Nekooeian, C C Pang
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P H McNultyT Caulin-Glaser
Apr 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P ZhaiD R Gross
Feb 5, 2002·Expert Opinion on Pharmacotherapy·O L Woodman
Apr 16, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Samir SabaBarry London
Sep 25, 2017·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Reza JabbariJacob Tfelt-Hansen
Jul 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Heidi L LujanStephen E DiCarlo
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I HernándezL F Carbonell

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