PMID: 12650708Mar 26, 2003Paper

17 beta-hydroxysteroid dehydrogenases and cancers

The Journal of Steroid Biochemistry and Molecular Biology
Pirkko VihkoVeli Isomaa

Abstract

17 beta-Hydroxysteroid dehydrogenases (17HSDs) catalyze the interconversions between active 17 beta-hydroxysteroids and less-active 17-ketosteroids thereby affecting the availability of biologically active estrogens and androgens in a variety of tissues. The enzymes have different enzymatic properties and characteristic cell-specific expression patterns, suggesting differential physiological functions for the enzymes. Epidemiological and endocrine evidence indicate that estrogens play a key role in the etiology of breast cancer while androgens are involved in mechanisms controlling the growth of prostatic cells, both normal and malignant. Recently, we have developed, using LNCaP prostate cancer cell lines, a cell model to study the progression of prostate cancer. In the model LNCaP cells are transformed in culture condition to more aggressive cells, able to grow in suspension cultures. Our results suggest that substantial changes in androgen and estrogen metabolism occur in the cells during the process. These changes lead to increased production of active estrogens during transformation of the cells. Data from studies of breast cell lines and tissues suggest that the oxidative 17HSD type 2 may predominate in human non-malignant...Continue Reading

References

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Citations

Sep 1, 1980·Journal of Steroid Biochemistry·A NimrodP Otto
May 8, 2004·Molecular and Cellular Endocrinology·R MindnichJ Adamski
Jul 24, 2010·Journal of Toxicology·Mette T Skaanild, Tina S Nielsen
Jun 4, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Atul GuptaArvind S Negi
Nov 7, 2006·The Journal of Steroid Biochemistry and Molecular Biology·R MindnichJ Adamski
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth J Folkerd, Mitch Dowsett
Mar 31, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·U HoppeO Hiort
May 28, 2020·International Journal of Molecular Sciences·Bagora BayalaJean-Marc A Lobaccaro
Dec 19, 2020·ACS Medicinal Chemistry Letters·Nicholas A ClantonDoug E Frantz
Dec 30, 2008·Molecular and Cellular Endocrinology·R Mindnich, J Adamski

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