17-Gene Genomic Prostate Score Test Results in the Canary Prostate Active Surveillance Study (PASS) Cohort.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Daniel W LinLisa F Newcomb

Abstract

The 17-gene Oncotype DX Genomic Prostate Score (GPS) test predicts adverse pathology (AP) in patients with low-risk prostate cancer treated with immediate surgery. We evaluated the GPS test as a predictor of outcomes in a multicenter active surveillance cohort. Diagnostic biopsy tissue was obtained from men enrolled at 8 sites in the Canary Prostate Active Surveillance Study. The primary endpoint was AP (Gleason Grade Group [GG] ≥ 3, ≥ pT3a) in men who underwent radical prostatectomy (RP) after initial surveillance. Multivariable regression models for interval-censored data were used to evaluate the association between AP and GPS. Inverse probability of censoring weighting was applied to adjust for informative censoring. Predictiveness curves were used to evaluate how models stratified risk of AP. Association between GPS and time to upgrade on surveillance biopsy was evaluated using Cox proportional hazards models. GPS results were obtained for 432 men (median follow-up, 4.6 years); 101 underwent RP after a median 2.1 years of surveillance, and 52 had AP. A total of 167 men (39%) upgraded at a subsequent biopsy. GPS was significantly associated with AP when adjusted for diagnostic GG (hazards ratio [HR]/5 GPS units, 1.18; 95% C...Continue Reading

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Citations

Jun 18, 2020·Cancers·Felipe CouñagoElia Del Cerro
Sep 19, 2020·Urology·Kevin B GinsburgUNKNOWN Michigan Urological Surgery Improvement Collaborative
Feb 17, 2021·World Journal of Urology· Banerjee, Sanoj Punnen
Feb 25, 2021·Nature Reviews. Urology·James L LiuAlan W Partin
Mar 4, 2021·World Journal of Urology·Colton H WalkerTodd M Morgan
Apr 10, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam B MurphyPeter H Gann
May 25, 2021·Frontiers in Oncology·Sophia C Kamran, Jason A Efstathiou
Jul 3, 2021·International Journal of Molecular Sciences·Belén Pastor-NavarroJosé Antonio López-Guerrero
Aug 7, 2021·Journal of Personalized Medicine·James MeehanArran K Turnbull

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