17-Hydroxyprogesterone in premature infants as a marker of intrauterine stress

Journal of Perinatal Medicine
Jörg ErschT Torresani

Abstract

Amniotic infection (AI) and preeclampsia (PE), which are commonly the reason for prematurity, inflict stress of different duration on immature fetuses. Whether chronic stress, as reflected by intrauterine growth retardation, influences the level of 17-OH progesterone (17-OHP), was not previously examined. We analyzed 17-OHP and TSH levels during neonatal screenings in the first hours of life of 90 premature infants born between 25 and 33 weeks of gestation in infants with AI (n=37) or with PE (n=53). Control of acute stress parameters was derived from umbilical arterial cord blood pH and base excess (BE). Mean 17-OHP levels of infants born to mothers with PE were 85.7 nmol/L compared to 54.6 nmol/L (P<0.001) in AI infants. 17-OHP was even higher when intrauterine growth restriction was present (99.8 nmol/L). Antenatal steroids and mode of delivery did not significantly affect 17-OHP levels. Stress of relatively long duration, as in cases of PE, leads to a significant increase of 17-OHP level in preterm infants. The postnatal 17-OHP level may be considered as a measure for severity of intrauterine stress and might be used as an individualized indicator for earlier intensive care.

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Citations

Nov 1, 2015·American Journal of Obstetrics and Gynecology·Kumanan WilsonJulian Little
Mar 14, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ernesto Carlos GonzálezJosé Luis Fernández
May 18, 2016·The Journal of Pediatrics·Luisa AguiarKsenia Tonyushkina
Feb 7, 2017·Annals of Pediatric Endocrinology & Metabolism·Seong Yong Lee
Nov 28, 2012·European Journal of Endocrinology·Amnon ZungShlomo Almashanu
Jun 9, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Belén Huidobro FernándezAmparo Rodríguez Sánchez
Dec 9, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·P Y TiehW-Np Lee
Feb 4, 2014·Metabolomics : Official Journal of the Metabolomic Society·Rebecca A HicksW P Lee
Oct 30, 2020·International Journal of Neonatal Screening·Patrice K HeldNatasha L Heather
Nov 27, 2020·International Journal of Neonatal Screening·Patrice K HeldNatasha L Heather
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

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