17-Methoxyl-7-Hydroxy-Benzene-Furanchalcone Ameliorates Myocardial Ischemia/Reperfusion Injury in Rat by Inhibiting Apoptosis and Autophagy Via the PI3K-Akt Signal Pathway

Cardiovascular Toxicology
Feifei XuanRenbin Huang

Abstract

17-Methoxyl-7-hydroxy-benzene-furanchalcone (MHBFC), a monomer isolated from the root of Millettia pulchra (Benth.) Kurz var. Laxior (Dunn) Z. Wei (Papilionaceae), has been demonstrated to exhibit protective effects on myocardial ischemia/reperfusion (I/R) injury in rats. However, the mechanisms for the effect are not completely clear. In the present study, we tested whether MHBFC could reduce I/R-induced apoptosis and overautophagy via the PI3K-Akt pathway. The rat I/R model was established by ligating the left anterior descending coronary artery for 30 min and then followed by reperfusion for 2 h. MHBFC (10 mg/kg, intravenously) was administered alone or along with LY294002 (PI3K inhibitor, 0.3 mg/kg, intravenously) 5 min before the onset of reperfusion. We found that MHBFC postconditioning prevented I/R-induced release of creatine kinase-MB and tumor necrosis factor-α, inhibited the opening of mitochondrial permeability transition pore, and promoted nitric oxide production. Additionally, MHBFC caused a significant increase in PI3K, phosphorylation of Akt, mammalian target of rapamycin, and endothelial nitric oxide synthase, and a decrease in the expression of cleaved caspase-3, Beclin1, and conversion of microtubule-associat...Continue Reading

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Citations

Jul 22, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Obaid S ShaikhThomas Cacciarelli
Aug 17, 2019·Frontiers in Cellular and Infection Microbiology·Puyuan TianTingtao Chen
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junhui HeJianchun Huang
Apr 2, 2021·International Journal of Cardiology·Ampadu O JacksonShiyin Long
Dec 14, 2021·Frontiers in Cell and Developmental Biology·Liuhua ZhouLiansheng Wang

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Methods Mentioned

BETA
ELISA
electrophoresis

Software Mentioned

SPSS
NIH Image

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