17beta-estradiol enhances cortical cholinergic innervation and preserves synaptic density following excitotoxic lesions to the rat nucleus basalis magnocellularis

Neuroscience
K M HorvathP G Luiten

Abstract

Estradiol exerts beneficial effects on neurodegenerative disorders associated with the decline of cognitive performance. The present study was designed to further investigate the effect of 17beta-estradiol on learning and memory, and to evaluate its neuroprotective action on cholinergic cells of the nucleus basalis magnocellularis, a neural substrate of cognitive performance. Female rats were ovariectomized at an age of 6 months. Three weeks later they received injections of either a mid-physiological dose of 17beta-estradiol or vehicle (oil), every other day for 2 weeks. The effect of estradiol on cognitive performance was tested in two associative learning paradigms. In the two-way active shock avoidance task estradiol-replaced animals learned significantly faster, while in the passive shock avoidance test no differences were observed between the experimental groups. Subsequent unilateral infusion of N-methyl-D-aspartate in the nucleus basalis magnocellularis resulted in a significant loss of cholinergic neurons concomitant with the loss of their fibers invading the somatosensory cortex. Estradiol treatment did not affect the total number of choline-acetyltransferase-immunoreactive neurons and their coexpression of the p75 lo...Continue Reading

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Citations

Oct 23, 2013·Cognitive, Affective & Behavioral Neuroscience·Wenhong DongYajun Xu
Jun 30, 2009·Psychoneuroendocrinology·István M AbrahámEva M Szego
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James W Simpkins, Meharvan Singh
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Apr 26, 2012·Journal of Neuroendocrinology·Z Kőszegi, I M Abrahám
Dec 25, 2004·Behavioural Brain Research·Karin Van der BorghtEddy A Van der Zee
Sep 16, 2015·Cellular and Molecular Neurobiology·Hui-Yun ChengPo-Ju Chu
May 4, 2004·The Lancet Oncology·Alessandro MinisiniLaura Biganzoli
Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·D Allan ButterfieldTanea Reed
Dec 22, 2016·International Journal of Molecular Sciences·Andrea KwakowskyRichard L Faull
Apr 30, 2009·Hearing Research·Jason A Miranda, Robert C Liu

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