17beta-Estradiol Induction of Filopodial Growth in Cultured Hippocampal Neurons within Minutes of Exposure

Molecular and Cellular Neurosciences
R E Brinton

Abstract

The rapid effect of 17beta-estradiol upon filopodial growth was investigated using videomicroscopy of hippocampal neurons in culture. Within 1-10 min, 17beta-estradiol induced a significant increase in the number of filopodia decorating neuritic extensions. In addition, the length of existing as well as newly formed filopodia increased significantly during the 10-min 17beta-estradiol exposure. Neurite area and neurite length did not change significantly. The inactive epimer, 17alpha-estradiol, had no effect upon any of the morphological parameters assessed. Similarly, neither progesterone or corticosterone showed a significant influence upon any of the parameters of hippocampal nerve cell growth in culture within the same time frame in which 17beta-estradiol effects were observed. Testosterone induced a significant increase in the number of filopodia without a significant increase in the overall length of the filopodia. Results of these studies demonstrate that 17beta-estradiol can induce rapid changes in nerve cell morphology, suggesting that modification of neuronal circuitry can occur within minutes of exposure, a time base that is consistent with 17beta-estradiol influence upon nerve cell excitability.

Citations

Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·M C Craig, D G Murphy
Dec 23, 2006·Journal of Neuroendocrinology·M C Craig, D G Murphy
Aug 27, 2010·Annals of the New York Academy of Sciences·Dani DumitriuJohn H Morrison
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P S Green, J W Simpkins
Feb 26, 1999·Journal of Neurophysiology·M R FoyT W Berger
Aug 31, 2018·Frontiers in Neuroscience·Chan-Chuan LiuNan-Shan Chang
Jul 3, 2002·Experimental Biology and Medicine·Lixia ZhaoRoberta Diaz Brinton
Jul 26, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jon NilsenRoberta Diaz Brinton
Feb 24, 2001·Annals of the New York Academy of Sciences·P S Green, J W Simpkins
Jan 6, 2001·Frontiers in Neuroendocrinology·P M WiseY Liu
Dec 17, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Laura BuggioPaolo Vercellini

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