17beta-estradiol rapidly enhances bradykinin signaling in primary sensory neurons in vitro and in vivo.

The Journal of Pharmacology and Experimental Therapeutics
Matthew P RowanWilliam P Clarke

Abstract

Many studies have demonstrated that premenopausal women are at increased risk for various pain disorders. Pain-sensing neurons, termed "nociceptors," in the trigeminal ganglia (TG) and dorsal root ganglia (DRG) express receptors for inflammatory mediators and noxious physical stimuli and transmit signals for central processing of pain sensation. Estrogen receptors (ERs) are also expressed on nociceptors in the TG and DRG, and there is ample literature to suggest that activation of ERs can influence pain mechanisms. However, the mechanism for ER modulation of nociceptor activity is incompletely understood. The aim of this study was to characterize the effect of 17β-estradiol (17β-E(2)) on signaling of the inflammatory mediator bradykinin (BK) in primary cultures of rat sensory neurons and a behavioral model of thermal allodynia in rats. Here, we show that exposure to 17β-E(2) rapidly (within 15 min) enhanced responses to BK in vitro and in vivo. The 17β-E(2)-mediated enhancement of BK signaling was not blocked by the transcription inhibitor anisomycin and was mediated by a membrane-associated ER. The effect of 17β-E(2) to enhance BK responses required activation of β1-containing, RGD-binding integrins. These data show that 17β-E...Continue Reading

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Citations

Aug 31, 2012·Current Pain and Headache Reports·Cristina TassorelliRossella E Nappi
Nov 8, 2011·Journal of Dental Research·A TashiroD A Bereiter
Jun 10, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nathaniel A JeskeRuben Gomez
Jun 26, 2015·Neurology·Maria G Cersosimo, Eduardo E Benarroch
Aug 25, 2015·The Journal of Pharmacology and Experimental Therapeutics·Raehannah J JamshidiKelly A Berg
Apr 8, 2014·The Journal of Pharmacology and Experimental Therapeutics·Matthew P RowanWilliam P Clarke
Feb 28, 2019·Frontiers in Integrative Neuroscience·David A BereiterMostafeezur Rahman

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