17beta-estradiol stimulates the growth of human keratinocytes by inducing cyclin D2 expression

The Journal of Investigative Dermatology
Naoko Kanda, Shinichi Watanabe

Abstract

Estrogen is reported to prevent age-associated epidermal thinning in the skin. We examined if 17beta-estradiol (E2) may enhance the growth of human keratinocytes, focusing on its effects on the expression of cell cycle-regulatory proteins. E2 enhanced proliferation, bromodeoxyuridine incorporation of keratinocytes, and increased the proportion of cells in the S phase. The E2-induced stimulation of proliferation and bromodeoxyuridine incorporation was suppressed by antisense oligonucleotide against cyclin D2, which induces G1 to S phase progression. E2 increased protein and mRNA levels of cyclin D2, and resultantly enhanced assembly and kinase activities of cyclin D2-cyclin-dependent kinases 4 or 6 complexes. E2 enhanced cyclin D2 promoter activity, and the element homologous to cAMP response element (CRE) on the promoter was responsible for the effect. Cyclin D2 expression was enhanced by antiestrogens, ICI 182,780 and 4-hydroxytamoxifen, and membrane-impermeable bovine serum albumin-conjugated E2, indicating the effects via membrane E2-binding sites. E2 increased the enhancer activity of CRE-like element and the amount of phosphorylated cAMP response element binding protein (CREB) binding this element, and the increases were s...Continue Reading

References

Sep 1, 1992·The British Journal of Dermatology·B A Gilchrest, M Yaar
Feb 10, 1989·Cell·M Beato
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jan 1, 1995·American Journal of Respiratory Cell and Molecular Biology·F WuD Warburton
Mar 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T C PappasC S Watson
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M AronicaB S Katzenellenbogen
Jan 1, 1997·British Journal of Cancer·R R TjandrawinataM Hughes-Fulford
Apr 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Y Gao, P S Zelenka
Feb 28, 1998·Genomics·B F O'DowdS R George
Sep 10, 1998·The Journal of Investigative Dermatology. Symposium Proceedings·J Campisi
Sep 10, 1998·The Journal of Investigative Dermatology. Symposium Proceedings·J VaraniJ J Voorhees
Mar 19, 1999·Journal of Cellular Physiology·K SayamaK Hashimoto
Aug 7, 1999·The Journal of Biological Chemistry·V ChaturvediB J Nickoloff
Aug 27, 1999·Journal of Cellular Biochemistry·V Le MellayM Lieberherr
Mar 17, 2001·Endocrinology·W P BentenF Wunderlich
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·M J Kelly, E R Levin
Jun 8, 2001·Journal of Neuroscience Research·K HondaA Akaike
Nov 14, 2001·American Journal of Clinical Dermatology·M G Shah, H I Maibach
Aug 8, 2002·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe
Nov 20, 2002·Biochemical and Biophysical Research Communications·Masayo FujitaSatoshi Inoue
Feb 27, 2003·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe
Dec 17, 2003·The Journal of Investigative Dermatology·Naoko Kanda, Shinichi Watanabe
Apr 1, 1946·Journal of Gerontology·M A GOLDZIEHER

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Citations

Nov 11, 2009·Breast Cancer Research and Treatment·Hugo Arias-PulidoMassimo Cristofanilli
May 28, 2009·Medical Oncology·Majid MojarradMohammad Hussein Modarressi
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Apr 16, 2011·The Journal of Biological Chemistry·Natasha C Lucki, Marion B Sewer
Feb 15, 2008·Annual Review of Physiology·Eric R ProssnitzHelen J Hathaway
Jul 1, 2006·Expert Opinion on Drug Discovery·Eric R ProssnitzTudor I Oprea
Jul 27, 2007·Climacteric : the Journal of the International Menopause Society·P-G SatorH Hönigsmann
Oct 22, 2015·Age·Barbara Rubek NielsenPeter Schwarz
Feb 12, 2008·Trends in Pharmacological Sciences·Eric R ProssnitzJeffrey B Arterburn
Feb 6, 2007·Clinics in Dermatology·Stephen C GilliverGillian S Ashcroft
Jan 26, 2006·Experimental Dermatology·Sylvie Verdier-SévrainBarbara Gilchrest
Apr 12, 2013·International Journal of Cosmetic Science·T MatamáA C Gomes
Mar 30, 2005·Journal of Dermatological Science·Naoko Kanda, Shinichi Watanabe
Aug 30, 2005·Trends in Endocrinology and Metabolism : TEM·Edward J Filardo, Peter Thomas
Jun 14, 2005·Expert Opinion on Therapeutic Targets·M J Thornton
Jun 5, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Wenwen ZhangXiaoxiang Guan
Feb 26, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Andrzej SlominskiRobert C Tuckey
Apr 22, 2009·Experimental Cell Research·Vassilia-Ismini AlexakiElias Castanas
Oct 26, 2013·Brain, Behavior, and Immunity·Bruna Romana-SouzaAndréa Monte-Alto-Costa
Oct 21, 2016·Reviews in Endocrine & Metabolic Disorders·Georgios NikolakisChristos C Zouboulis
Oct 24, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michele Conceição PereiraJacks Jorge
May 12, 2009·Steroids·Yayoi TadaShinichi Watanabe
May 19, 2009·Technology in Cancer Research & Treatment·G TuT Yu
Jul 13, 2018·Journal of Virology·Yonggang PeiErle S Robertson
Sep 12, 2015·Journal of Menopausal Medicine·Mi-Jin KimHae-Hyeog Lee
Jan 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Inkeri TialaOuti Elomaa
Apr 20, 2010·Annals of the New York Academy of Sciences·Stefano SoldanoMaurizio Cutolo
Aug 1, 2006·Endocrine Reviews·Ulrich OhnemusRalf Paus
Jan 5, 2016·Molecular Endocrinology·Alice K TreenDenise D Belsham
Jan 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gertrude-E Costin, Vincent J Hearing
Oct 22, 2011·Climacteric : the Journal of the International Menopause Society·Debora Yankelevich
Apr 2, 2015·Experimental Dermatology·Georgios NikolakisChristos C Zouboulis
Jun 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ya-Ching HsiehIrshad H Chaudry
Oct 6, 2007·Endocrine Reviews·Stephen R Hammes, Ellis R Levin
Apr 29, 2006·Molecular Endocrinology·Ali PedramEllis R Levin
Apr 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·X Lin, T Huang

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