17beta-estradiol treatment decreases steroidogenic enzyme messenger ribonucleic acid levels in the rainbow trout testis

Endocrinology
M GovorounY Guiguen

Abstract

In fish, estrogens are well known for their involvement in ovarian differentiation and have been shown to be very potent feminizing agents when administrated in vivo during early development. However, the mechanism of action of exogenous estrogens is poorly understood. We report here on the feminizing effects of estrogen treatment on the testicular levels of some steroidogenic enzyme messenger RNAs [mRNAs; cholesterol side-chain cleavage (P450scc), 17-hydroxylase/lyase (P450c17), 3beta-hydroxysteroid dehydrogenase (3betaHSD), 11beta-hydroxylase (P45011beta), and aromatase (P450aro)] in the rainbow trout, Oncorhynchus mykiss. Treatment was carried out by dietary administration of 17beta-estradiol (E(2); dosage of 20 mg/kg diet) to a genetically all male population. Steroidogenesis in the differentiating testis was demonstrated to be strongly altered by E(2), as this treatment resulted in considerable decrease in P450c17, 3betaHSD, and P45011beta mRNAs after only 10 days of treatment. In contrast, P450scc and P450aro mRNA levels were unaffected by E(2), with P450scc mRNA levels remaining unaltered and P450aro not stimulated by this feminizing estrogen treatment. To better characterize this E(2) effect, the same treatment was appl...Continue Reading

References

Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·T M JonesR Rosenfield
Mar 1, 1991·General and Comparative Endocrinology·S FasanoR Pierantoni
Jan 1, 1988·Archives of Andrology·M NamikiT Sonoda
Mar 1, 1988·The Journal of Heredity·B ChevassusB Jalabert
Feb 1, 1985·General and Comparative Endocrinology·R van den Hurk, P G van Oordt
Nov 21, 1996·Nature·S GimenoH Komen
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K I Morohashi, T Omura
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K M RobertsonE R Simpson
Jul 21, 1999·Cellular and Molecular Life Sciences : CMLS·K L ParkerA Schedl
Jul 21, 1999·Cellular and Molecular Life Sciences : CMLS·C PieauN Richard-Mercier
Sep 27, 2002·International Journal of Population Geography : IJPG·T Tammaru, O Sjoberg

❮ Previous
Next ❯

Citations

Dec 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fuminori TaniguchiKenneth S Korach
Jun 1, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Robert A AngusR Douglas Watson
Oct 23, 2002·Environmental Toxicology and Chemistry·Sirinmas KatchamartDonald R Buhler
Jan 15, 2015·General and Comparative Endocrinology·María Florencia ScaiaNora Raquel Ceballos
Nov 21, 2019·Molecular Reproduction and Development·Lihui MengXubo Wang
May 20, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jorge M NaciffGeorge P Daston
Jun 24, 2020·Environmental Science and Pollution Research International·Tatiana GuellardBartłomiej Arciszewski
Sep 12, 2018·International Journal of Molecular Sciences·Dongdong LiangFeng You
Apr 2, 2010·Environmental Science & Technology·Anel M Flores-ValverdeElizabeth M Hill

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.