17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis.

Seminars in Reproductive Medicine
S E BulunEmily J Su

Abstract

Estradiol (E2) stimulates the growth and inflammation in the ectopic endometriotic tissue that commonly resides on the pelvic organs. Several clinical and laboratory-based observations are indicative of resistance to progesterone action in endometriosis. The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptor (PR). In normal endometrium, progesterone acts via PR on stromal cells to induce secretion of paracrine factor(s) that in turn stimulate neighboring epithelial cells to express the enzyme 17beta-hydroxysteroid dehydrogenase type 2 (HSD17B2). HSD17B2 is an extremely efficient enzyme and rapidly metabolizes the biologically potent estrogen E2 to weakly estrogenic estrone. In endometriotic tissue, progesterone is incapable of inducing epithelial HSD17B2 expression due to a defect in stromal cells. The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate HSD17B2 may be due to the very low levels of PR observed in vivo in endometriotic tissue. The end result is deficient metabolism of E2 in endometriosis giving rise to high local concentrations of this mitogen. The molecular details of this ...Continue Reading

Citations

Feb 22, 2012·Reproductive Sciences·Maricarmen Colón-DíazIdhaliz Flores
Apr 24, 2012·Reproductive Biology and Endocrinology : RB&E·Nicolas SamartzisPatrick Imesch
Sep 11, 2012·Journal of Animal Science and Biotechnology·Fuller W BazerGuoyao Wu
Aug 13, 2010·The Journal of Clinical Endocrinology and Metabolism·Mary Ellen PavoneYou-Hong Cheng
Jul 12, 2013·Obstetrics and Gynecology International·Antonio Simone LaganàOnofrio Triolo
Mar 19, 2014·Human Reproduction Update·Sang Jun Han, Bert W O'Malley
Jan 23, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Eleftherios P SamartzisBrigitte Leeners
Sep 4, 2015·Reproductive Sciences·Stephen S PalmerSelvaraj G Nataraja
Jul 3, 2016·Reproductive Sciences·Peter A W RogersUNKNOWN WES/WERF Consortium for Research Priorities in Endometriosis
Apr 11, 2018·The Journal of Endocrinology·Yeon Jean ChoSang Jun Han
Mar 1, 2011·Hormone Molecular Biology and Clinical Investigation·Gerhard Leyendecker, Ludwig Wildt
Jan 11, 2019·Science Translational Medicine·Tae Hoon KimJae-Wook Jeong
Jul 22, 2018·Journal of Molecular Endocrinology·Carla A PiccinatoPhilippa T K Saunders
Feb 1, 2017·Reproductive Sciences·A W PeterUNKNOWN WES/WERF Consortium for Research Priorities in Endometriosis
Apr 4, 2021·Journal of Clinical Medicine·Jacques Donnez, Marie-Madeleine Dolmans
Sep 25, 2012·Fertility and Sterility·Mary Ellen Pavone, Serdar E Bulun
May 7, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohummad Hasan Raza RajaRehana Rehman
Nov 5, 2017·Fertility and Sterility·Stephan GordtsIvo Brosens

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