17Beta-oestradiol enhances the acute hypotensive effect of captopril in female ovariectomized spontaneously hypertensive rats

Experimental Physiology
José GiménezIsabel Hernández

Abstract

The objective of this study was to investigate whether the acute haemodynamic effects of angiotensin-converting enzyme inhibition with captopril could be enhanced by oestrogen administration, and then to evaluate the mechanisms involved in this enhancement. All experiments were performed in 18-week-old female spontaneously hypertensive rats arranged in three experimental groups: intact; ovariectomized (OVX); and ovariectomized plus treatment with 17beta-oestradiol (OVX + E2). These groups were used to evaluate the effects of captopril administration alone, or following bradykinin B2 receptor blockade or nitric oxide synthase inhibition, on a number of haemodynamic parameters (mean arterial pressure, cardiac index, vascular resistance and heart rate). The drop in mean arterial pressure and vascular resistance index in response to captopril was more pronounced in intact and ovariectomized rats treated with 17beta-oestradiol than in ovariectomized animals. Blockade of bradykinin B2 receptors or inhibition of nitric oxide synthesis attenuated the synergy between 17beta-oestradiol and captopril. It is concluded that ovariectomy blunted the blood pressure and vascular resistance index drop observed in intact rats in response to capto...Continue Reading

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Citations

Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Madhan SubramanianP S MohanKumar
Sep 25, 2007·The Journal of Sexual Medicine·Jorge E ToblliAmado J Bechara
Oct 15, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D P M DiasR Fazan
Jul 9, 2010·Fundamental & Clinical Pharmacology·Kimiaki KomukaiMichihiro Yoshimura
Oct 21, 2019·Vascular Pharmacology·Manal FardounAli H Eid

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