17p anomalies in lymphoid malignancies: diagnostic and prognostic implications

Leukemia & Lymphoma
Claudia SchochC Fonatsch

Abstract

Eighteen patients with lymphoid malignancies and abnormalities of the short arm of chromosome 17 were evaluated, in order to analyse whether this anomaly was associated with a particular subgroup of lymphoid malignancies. The patients suffered from acute lymphoblastic leukemia, high-grade non-Hodgkin's lymphoma or plasma cell leukemia. No 17p anomaly was found in any patient with chronic lymphocytic leukemia or low-grade non-Hodgkin's lymphoma. In four cases the aberration of the short arm of chromosome 17 was the sole cytogenetic abnormality, in fourteen patients additional chromosomal aberrations were found. Five out of 18 cases were Burkitt's lymphoma/leukemia showing the typical rearrangement of 8q24. In cases with a karyotype evolution the 17p anomaly was always a late event. Concerning the clinical outcome of the patients with abnormalities of the short arm of chromosome 17 eight of nineteen patients died within 90 days after the diagnosis of the 17p anomaly only three were alive at the last follow up (26 months to 40 months after diagnosis of a 17p aberration). Rearrangements of 17p, especially as secondary cytogenetic events, seem to be associated with a poor clinical outcome in lymphoid malignancies.

References

Mar 1, 1992·The Journal of Pathology·R VilluendasP Martinez
Nov 1, 1992·Journal of Clinical Pathology·Y SoiniK Vähäkangas
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Sep 15, 1992·Cancer·S Heim, F Mitelman
Jul 2, 1992·Nature·D P Lane
Dec 1, 1991·British Journal of Haematology·M A RodriguezA B Deisseroth
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 1, 1991·The Journal of Clinical Investigation·H AhujaM Cline
Jun 6, 1991·Nature·A J LevineC A Finlay
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G GaidanoR Dalla-Favera
Jan 1, 1990·Genes & Development·D P Lane, S Benchimol
Oct 15, 1990·Cancer Genetics and Cytogenetics·P Jonveaux, R Berger
Mar 1, 1990·Genes, Chromosomes & Cancer·E G LevineB A Peterson
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jan 1, 1988·Annals of Internal Medicine·E G LevineC D Bloomfield
Aug 1, 1986·Cancer Genetics and Cytogenetics·S Heim, F Mitelman
Mar 1, 1987·Cancer Genetics and Cytogenetics·U KristofferssonF Mitelman
Feb 1, 1982·Cancer Genetics and Cytogenetics·G H BorgströmA de la Chapelle
Dec 15, 1980·International Journal of Cancer. Journal International Du Cancer·C FonatschV Diehl

❮ Previous
Next ❯

Citations

Nov 7, 2000·Cancer Genetics and Cytogenetics·E LloverasL Florensa
Jan 22, 2002·Cancer Genetics and Cytogenetics·Lourdes ZamoraSoledad Woessner
Feb 27, 2007·Cancer Genetics and Cytogenetics·Adewale AdeyinkaJessica Sanchez
Sep 5, 1998·Cancer Treatment Reviews·D W HammondM H Goyns
Oct 31, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J L Hecht, J C Aster

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.