PMID: 11341367May 9, 2001Paper

1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock

The Journal of Pharmacy and Pharmacology
F A SantosV L De Souza

Abstract

The effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg(-1), i.p.) and LPS (5 microg kg(-1), i.p.) greatly elevated serum concentrations of tumour necrosis factor-alpha (TNF-alpha), alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic necrosis and lethality in 100% of control mice. Pretreatment with 1,8-cineole (400 mg kg(-1), p.o.) and dexamethasone (1 mg kg(-1), s.c.), 60 min before GalN/LPS, offered complete protection (100%) against the lethal shock and acute elevation in serum TNF-alpha and serum transaminases. Hepatic necrosis induced by GalN/LPS was also greatly reduced by both 1,8-cineole and dexamethasone treatment. The results indicate that 1,8-cineole protects mice against GalN/LPS-induced liver injury through the inhibition of TNF-alpha production, and suggest that 1,8-cineole may be a promising agent to combat septic-shock-associated pathologies.

References

May 1, 1992·Infection and Immunity·G TiegsA Wendel
Jan 1, 1991·Pharmaceutical Research·A C Williams, B W Barry
Jun 1, 1994·Pulmonary Pharmacology·E A LaudeT J Grattan
Mar 15, 1993·Biochemical and Biophysical Research Communications·A RojasS Moncada
Jun 1, 1996·The Journal of Infectious Diseases·S M OpalC Donsky
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Jul 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P LissoniV Chatikhine
May 22, 1998·Journal of Cardiovascular Pharmacology·T ShindoY Yazaki
Aug 1, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Gao, J Singh
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M D JosephsL L Moldawer
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M NowakL L Moldawer

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Citations

Mar 17, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F A SantosV S N Rao
May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Vasco P D BastosPedro Jorge Caldas Magalhães
Feb 5, 2003·Canadian Journal of Physiology and Pharmacology·Saad LahlouJosé Henrique Leal-Cardoso
Jul 9, 2014·BMC Complementary and Alternative Medicine·Aleksandar RaškovićMomir Mikov
May 30, 2015·International Journal of Molecular Sciences·Soichiro MurataNobuhiro Ohkohchi
Sep 27, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S McLeanJ S Sorensen
Jun 11, 2014·Archives of Toxicology·Bastian DörsamJörg Fahrer
Jul 23, 2013·Biochimica Et Biophysica Acta·Johannes F-W GreinerChristian Kaltschmidt
Aug 6, 2015·PloS One·Germana Freire Rocha CaldasAlmir Gonçalves Wanderley
Sep 8, 2016·Pulmonary Pharmacology & Therapeutics·Emanuel Kennedy-FeitosaSamuel Santos Valenca
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Germana Freire Rocha CaldasAlmir Gonçalves Wanderley
Jan 27, 2018·Journal of Translational Medicine·Ajaikumar B KunnumakkaraBharat B Aggarwal
Jan 9, 2013·Phytotherapy Research : PTR·Adriana G GuimarãesLucindo J Quintans
Feb 18, 2017·Inflammopharmacology·José de Maria de Albuquerque de Melo JúniorAdriana Rolim Campos
Nov 13, 2018·Pakistan Journal of Biological Sciences : PJBS·Sahar Y Al-OkbiMohamed E Hassan
Oct 29, 2020·Journal of Asian Natural Products Research·Zi-Min CaiXiang-Chun Shen
Nov 6, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jullyana S S QuintansLucindo J Quintans-Júnior
Oct 9, 2021·BMC Complementary Medicine and Therapies·Mira Nadiah Mohd IzhamNoorjahan Banu Alitheen

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