18 F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab

European Journal of Hybrid Imaging
Pacôme FosseRoland Hustinx

Abstract

18F-FDG PET/CT has been proposed in the evaluation of the disease activity in rheumatoid arthritis (RA). The goals of this study were to evaluate the reproducibility of the technique, to compare metabolic parameters to clinical, biological and ultrasonographic parameters before and after treatment and to evaluate whether the early metabolic response was related to the outcome. 18F- FDG PET/CT of the hands, wrists and knees was obtained in 15 patients with anti-TNFα refractory RA, at baseline and 16 weeks after treatment with rituximab. The number of PET-positive joints (PET+ joints), the cumulative standard uptake value (cSUV) and the composite index (CI) were defined. The composite clinical index DAS28, CRP serum levels and the number of joints positive at ultrasonography (US+ joints) and the cumulative synovial thickness (CST) were also assessed at baseline and week 24. High interobserver agreement was observed, both at baseline and after treatment. The number of PET+ joints was not correlated with the number of joints tender or swollen. The 3 metabolic parameters were strongly correlated with US, CRP and DAS28 at baseline and with US and CRP (CSUV, CI) at week 16, but no longer with the DAS28 index. The metabolic response ba...Continue Reading

References

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Citations

Mar 5, 2018·Rheumatology and Therapy·Andrea Rubbert-RothErhan Berber
Sep 30, 2020·Seminars in Musculoskeletal Radiology·Chiara GiraudoSiegfried Trattnig
May 30, 2019·Journal of Clinical Medicine·Elsa Sanchez-LopezMonica Guma
Jan 22, 2021·Autoimmunity Reviews·Jeffrey M A van der KrogtSander W Tas
Feb 17, 2021·PET Clinics·William Y RaynorMona-Elisabeth Revheim
Nov 22, 2020·PET Clinics·Abhijit J ChaudhariAbass Alavi

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Methods Mentioned

BETA
imaging technique
imaging techniques

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