18 F-FDG PET/CT metabolic tumor parameters and radiomics features in aggressive non-Hodgkin's lymphoma as predictors of treatment outcome and survival

Annals of Nuclear Medicine
Aatif ParvezUr Metser

Abstract

To determine whether metabolic tumor parameters and radiomic features extracted from 18F-FDG PET/CT (PET) can predict response to therapy and outcome in patients with aggressive B-cell lymphoma. This institutional ethics board-approved retrospective study included 82 patients undergoing PET for aggressive B-cell lymphoma staging. Whole-body metabolic tumor volume (MTV) using various thresholds and tumor radiomic features were assessed on representative tumor sites. The extracted features were correlated with treatment response, disease-free survival (DFS) and overall survival (OS). At the end of therapy, 66 patients (80.5%) had shown complete response to therapy. The parameters correlating with response to therapy were bulky disease > 6 cm at baseline (p = 0.026), absence of a residual mass > 1.5 cm at the end of therapy CT (p = 0.028) and whole-body MTV with best performance using an SUV threshold of 3 and 6 (p = 0.015 and 0.009, respectively). None of the tumor texture features were predictive of first-line therapy response, while a few of them including GLNU correlated with disease-free survival (p = 0.013) and kurtosis correlated with overall survival (p = 0.035). Whole-body MTV correlates with response to therapy in patien...Continue Reading

References

Nov 17, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ronald BoellaardBernd J Krause
Mar 13, 2012·International Journal of Molecular Sciences·Salvador J Diaz-Cano
Aug 18, 2012·Magnetic Resonance Imaging·Virendra KumarRobert J Gillies
Aug 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally F BarringtonBruce D Cheson
Feb 24, 2016·European Journal of Nuclear Medicine and Molecular Imaging·N George MikhaeelSally F Barrington
Mar 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne-Ségolène CottereauStéphanie Becker

❮ Previous
Next ❯

Citations

Jul 12, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Isabella CastiglioniMarco Salvatore
Nov 24, 2019·Annals of Nuclear Medicine·Seigo Kinuya
Jul 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Marius E MayerhoeferHeiko Schöder
Nov 7, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniMargarita Kirienko
Sep 15, 2020·Annals of Nuclear Medicine·Juan Carlos Prieto PrietoChrissa Sioka
May 31, 2020·European Radiology·Hongxi WangRong Tian
Jan 30, 2020·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Coreline N BurggraaffUNKNOWN PETRA Consortium
Aug 4, 2020·World Journal of Clinical Cases·Xin-Yue Zhang, Zhi-Ming Wang
Jul 8, 2020·Methods : a Companion to Methods in Enzymology·Marius E MayerhoeferHeiko Schöder
Dec 6, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A-S CottereauI Buvat
Oct 23, 2020·Nuclear Medicine and Molecular Imaging·Ayşegül AksuGamze Çapa Kaya
Feb 23, 2021·Nihon Hoshasen Gijutsu Gakkai zasshi·Takuro Shiiba
Mar 7, 2021·Diagnostics·Manuel Piñeiro-FielPablo Aguiar
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Virginia LiberiniDésirée Deandreis
Oct 13, 2019·Journal of Nuclear Medicine Technology·Mariana R CamachoCelso D Ramos
Jul 1, 2021·European Journal of Hybrid Imaging·Martina SolliniArturo Chiti
Aug 19, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Jakoba J EertinkJosée M Zijlstra
Jun 3, 2021·Nuclear Medicine Communications·Nazim CoskunMehmet Tevfik Kitapci
Jan 16, 2022·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Han JiangHong Zhang
Jan 15, 2022·Annals of Nuclear Medicine·Kenji HirataKohsuke Kudo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.