May 7, 2019

18 F]-Fludarabine for Hematological Malignancies

Frontiers in Medicine
Louisa BarréGandhi Damaj

Abstract

With the emergence of PET/CT using 18F-FDG, molecular imaging has become the reference for lymphoma lesion detection, tumor staging, and response assessment. According to the response in some lymphoma subtypes it has also been utilized for prognostication of disease. Although 18F-FDG has proved useful in the management of patients with lymphoma, the specificity of 18F-FDG uptake has been critically questioned, and is not without flaws. Its dependence on glucose metabolism, which may indiscriminately increase in benign conditions, can affect the 18F-FDG uptake in tumors and may explain the causes of false-positive imaging data. Considering these drawbacks, 18F-fludarabine, an adenine nucleoside analog, was developed as a novel PET imaging probe. An efficient and fully automated radiosynthesis has been implemented and, subsequently preclinical studies in xenograft murine models of hematological maligancies (follicular lymphoma, CNS lymphoma, multiple myeloma) were conducted with this novel PET probe in parallel with 18F-FDG. The results demonstrated several crucial points: tumor-specific targeting, weaker uptake in inflammatory processes, stronger correlation between quantitative values extracted from [18]F-fludarabine and histol...Continue Reading

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Mentioned in this Paper

Molecular Imaging
Study
Nucleoside Analogs
Hematologic Neoplasms
Lymphoma Stage I
Bone Marrow
Brain
PET/CT scan
Uptake
Neoplasms

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