18 F]-Fluorinated Carboplatin and [111 In]-Liposome for Image-Guided Drug Delivery

International Journal of Molecular Sciences
Narottam LamichhaneJamal Zweit

Abstract

Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as both a radiolabeled drug and radiolabeled carrier. The approach has the potential for clinical translation in individual patients using a dual modal approach of clinically-relevant radionuclides of 18F positron emission tomography (PET) and 111In single photon emission computed tomography (SPECT). [111In]-Liposome was synthesized and evaluated in vivo by biodistribution and SPECT imaging. The [18F]-FCP encapsulated [111In]-Liposome nano-construct was investigated, in vivo, using an optimized dual-tracer PET and SPECT imaging in a nude mouse. The biodistribution data and SPECT imaging showed spleen and liver uptake of [111In]-Liposome and the subsequent clearance of activity with time. Dual-modality imaging of [18F]-FCP encapsulated [111In]-Liposome showed significant uptake in liver and spleen in both PET and SPECT images. Qualitative analys...Continue Reading

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Citations

Aug 8, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Francis ManRafael T M de Rosales
Feb 2, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Narottam LamichhaneJaved Mahmood
Mar 19, 2021·Current Opinion in Chemical Biology·Aurora BernalCarlos Pérez-Medina
Jun 21, 2020·Chemistry and Physics of Lipids·Liliana Aranda-LaraKeila Isaac-Olivé
Jul 30, 2020·Advanced Drug Delivery Reviews·Carlos Pérez-MedinaRoy van der Meel

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

OSEM3D
IRW
Inveon Research Workplace ( IRW )

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