18 F-fluorodeoxyglucose positron emission tomography (18 FDG-PET) for patients with biliary tract cancer: Systematic review and meta-analysis

Journal of Hepatology
Angela LamarcaJuan W Valle

Abstract

The role of 18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) in the diagnosis and staging of patients with biliary tract cancers (BTCs) remains controversial, so we aimed to provide robust information on the utility of 18FDG-PET in the diagnosis and management of BTC. This systematic review and meta-analysis explored the diagnostic test accuracy of 18FDG-PET as a diagnostic tool for diagnosis of primary tumour, lymph node invasion, distant metastases and relapsed disease. Subgroup analysis by study quality and BTC subtype were performed. Changes in management based on 18FDG-PET and impact of maximum standardised uptake values (SUVmax) on prognosis were also assessed. A random effects model was used for meta-analyses. A total of 2,125 patients were included from 47 eligible studies. The sensitivity (Se) and specificity (Sp) of 18FDG-PET for the diagnosis of primary tumour were 91.7% (95% CI 89.8-93.2) and 51.3% (95% CI 46.4-56.2), respectively, with an area under the curve (AUC) of 0.8668. For lymph node invasion, Se was 88.4% (95% CI82.6-92.8) and Sp was 69.1% (95% CI 63.8-74.1); AUC 0.8519. For distant metastases, Se was 85.4% (95% CI 79.5-90.2) and Sp was 89.7% (95% CI86.0-92.7); AUC 0.9253. For relapse, Se was...Continue Reading

Citations

Mar 5, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Alejandro FornerAngela Lamarca
Jul 2, 2020·Nature Reviews. Gastroenterology & Hepatology·Jesus M BanalesGregory J Gores
Jan 24, 2020·Current Medicinal Chemistry·Angela LamarcaJuan W Valle
Sep 8, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Cholangiocarcinoma Working Group
Feb 1, 2021·Lancet·Juan W ValleAndrew X Zhu
Feb 4, 2021·Current Problems in Surgery·T Peter KinghamMichael I D'Angelica
Sep 22, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Cholangiocarcinoma Working Group
Jul 30, 2020·Radiology and Oncology·Ilenia BartoliniPaolo Muiesan
May 28, 2021·World Journal of Gastrointestinal Oncology·Gianluca RompianesiRoberto Troisi
Jul 3, 2021·Cancers·Pedro M RodriguesJesus M Banales
Aug 10, 2021·World Journal of Gastroenterology : WJG·Nikolaos FragkouEmmanouil Sinakos
Aug 21, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Carlo SpositoVincenzo Mazzaferro
Aug 17, 2021·Radiologic Clinics of North America·Brandon A Howard, Terence Z Wong
Sep 11, 2021·Nature Reviews. Disease Primers·Paul J BrindleyGregory J Gores
Oct 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Samuel J GalganoJonathan E McConathy
Jan 16, 2022·ESMO Open·A LamarcaL Goyal

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