18 F-Sodium fluoride uptake is associated with severity of atherosclerotic stenosis in stable ischemic heart disease

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Artineh HayrapetianYuxin Li

Abstract

Increased uptake of 18F-Sodium fluoride (18F-NaF) PET has potential to identify atherosclerotic plaques that are vulnerable to rupture. Whether 18F-NaF PET can evaluate the significance of atherosclerotic plaque in patients with stable coronary artery disease is less clear. We evaluated 18F-NaF PET uptake in coronary arteries in patients without acute coronary artery syndrome to determine the association of 18F-NaF signal uptake with severity of coronary stenosis. We retrospectively identified 114 patients who received both regadenoson stress 82Rb myocardial perfusion PET and 18F-NaF PET study with an average interval of 5 months. Out of this cohort, forty-one patients underwent invasive coronary angiography. In a patient-based analysis, patients with ischemic regadenoson stress 82Rb PET had significantly higher coronary 18F-NaF uptake than patients with normal myocardial perfusion (P < .01). Among the 41 patients who underwent coronary angiography, per-vessel 18F-NaF uptake in both obstructive and nonobstructive coronary arteries was significantly higher than in normal coronary arteries (P < .05) regardless of the severity of coronary calcification. There was poor correlation between calcification and 18F-NaF uptake in coronar...Continue Reading

References

Mar 28, 2008·The New England Journal of Medicine·Robert DetranoRichard A Kronmal
May 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James H F RuddZahi A Fayad
Nov 6, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·George SegallUNKNOWN SNM
Apr 21, 2012·Journal of the American College of Cardiology·Marc R DweckDavid E Newby
Nov 20, 2013·JAMA : the Journal of the American Medical Association·Michael H CriquiMatthew A Allison
May 9, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francesco FizGianmario Sambuceti
Jul 8, 2015·Nature Communications·Agnese IrkleAnthony P Davenport
Feb 9, 2016·Expert Review of Cardiovascular Therapy·Mhairi K Doris, David E Newby
Nov 1, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Björn A BlombergPoul F Høilund-Carlsen
Mar 30, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Yoshinobu IshiwataTomio Inoue
Dec 12, 2017·Journal of Atherosclerosis and Thrombosis·Teruo NoguchiSatoshi Yasuda
Jan 23, 2018·Clinical Cardiology·Isac C ThomasMichael H Criqui
Sep 10, 2018·Trends in Cardiovascular Medicine·Matthieu Pelletier-Galarneau, Terrence D Ruddy

❮ Previous
Next ❯

Citations

Jul 24, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Michael T OsborneMazen S Albaghdadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.