18 F]DOPA PET/ceCT in diagnosis and staging of primary medullary thyroid carcinoma prior to surgery

European Journal of Nuclear Medicine and Molecular Imaging
Sazan RasulMarkus Hartenbach

Abstract

Medullary thyroid carcinoma (MTC) is characterized by a high rate of metastasis. In this study we evaluated the ability of [18F]DOPA PET/ceCT to stage MTC in patients with suspicious thyroid nodules and pathologically elevated serum calcitonin (Ctn) levels prior to total thyroidectomy and lymph node (LN) dissection. A group of 32 patients with sonographically suspicious thyroid nodules and pathologically elevated basal Ctn (bCtn) and stimulated Ctn (sCtn) levels underwent DOPA PET/ceCT prior to surgery. Postoperative histology served as the standard of reference for ultrasonography and DOPA PET/ceCT region-based LN staging. Univariate and multivariate regression analyses as well as receiver operating characteristic analysis were used to evaluate the correlations between preoperative and histological parameters and postoperative tumour persistence or relapse. Primary MTC was histologically verified in all patients. Of the 32 patients, 28 showed increased DOPA decarboxylase activity in the primary tumour (sensitivity 88%, mean SUVmax 10.5). Undetected tumours were exclusively staged pT1a. The sensitivities of DOPA PET in the detection of central and lateral metastatic neck LN were 53% and 73%, in contrast to 20% and 39%, respecti...Continue Reading

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Citations

Sep 5, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Luca GiovanellaMarkus Luster
Jun 5, 2020·Reviews in Endocrine & Metabolic Disorders·Julie RefardtEmanuel Christ
Oct 12, 2018·Annals of Surgical Oncology·Lindsay BrammenBruno Niederle
Nov 17, 2020·Thyroid : Official Journal of the American Thyroid Association·Fréderic Castinetti, David Taïeb
Jan 17, 2021·Revista española de medicina nuclear e imagen molecular·S AriciŞ Cihan
Nov 5, 2021·Current Oncology Reports·Julie RefardtEmanuel Christ

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