18 F]Fluorodeoxyglucose-positron emission tomography/computed tomography response evaluation can predict histological response at surgery after induction chemotherapy for oligometastatic bladder cancer

Scandinavian Journal of Urology
Petter KollbergFredrik Liedberg

Abstract

Patients with limited metastatic and locally advanced bladder cancer have a poor prognosis, and no definite treatment recommendations exist. However, long-term survival is possible for selected patients if surgery is combined with multiple courses of chemotherapy (i.e. induction chemotherapy). Patients with tumours that are insensitive to chemotherapy probably have little to gain from subsequent extensive surgery. The aim of this study was to evaluate sequential FDG-PET/CT examinations as an indicator of chemotherapy response. Between 2007 and 2015, 50 patients with oligometastatic invasive bladder cancer selected for induction chemotherapy underwent two FDG-PET/CT examinations: the first before the start of chemotherapy and the second after three courses of cisplatinum-based combination chemotherapy. Responders were given up to six courses of chemotherapy. FDG-PET/CT response was correlated with histological response in excised lymph-node metastases. Three patients showed progression to incurable disease during chemotherapy and another two patients did not undergo surgery, for medical reasons. Lymphadenectomy was performed in the remaining 45 patients, of whom 43 had lymph-node metastasis. FDG-PET/CT prediction of the histolog...Continue Reading

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Citations

Jul 24, 2020·Current Opinion in Urology·Sarah M H EinerhandBas W G van Rhijn
Nov 21, 2018·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Ebru SalmanogluMathew L Thakur
Oct 30, 2020·Frontiers in Oncology·Antoine GirardMathieu Rouanne
May 8, 2021·Journal of the American College of Radiology : JACR·UNKNOWN Expert Panel on Urological ImagingMark E Lockhart

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