180 ml and less: cardiopulmonary bypass techniques to minimize hemodilution for neonates and small infants

Perfusion
Kevin CharetteRalph Mosca

Abstract

To determine the efficacy of decreasing cardiopulmonary bypass (CPB) prime volume for neonates and small infants by using low prime oxygenators, small diameter polyvinyl chloride (PVC) tubing and removing the arterial line filter (ALF) in an effort to reduce intraoperative exposure to multiple units of packed red blood cells (PRBC). Two retrospective database studies comparing neonatal CPB prime volume were undertaken: Study 1--A CPB circuit consisting of a 1/8 inch arterial line, a 3/16 inch venous line and a low prime oxygenator with 172 ml total circuit prime (n=74) was compared to a circuit with a 3/16 inch arterial line, a 1/4 inch venous line and a higher prime oxygenator with a 350 ml total circuit prime (n=74). Study 2--The 172 ml circuit (n=389) was compared to a circuit that included an ALF and had a total circuit prime volume of 218 ml (n=389). Study 1--of the 74 neonates and small infants whose CPB prime volume was 350 ml, 19 were exposed to two or more intraoperative exogenous PRBC units while only 3 neonates and small infants in the 172 ml prime group (n=74) received two or more units (p = 0.0002). Study 2--of the 389 neonates and small infants where an ALF was used (prime volume 218 ml), 54 were exposed to two or...Continue Reading

References

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Citations

Dec 9, 2010·Artificial Organs·Yves Durandy
Apr 22, 2014·Journal of Cardiothoracic and Vascular Anesthesia·Asli Dönmez, Okan Yurdakök
Dec 16, 2010·Paediatric Anaesthesia·Michael P Eaton, Ellen M Iannoli
Aug 27, 2014·The Journal of Thoracic and Cardiovascular Surgery·David KalfaEmile Bacha
May 21, 2009·Perfusion·E Hirleman, D F Larson
May 31, 2014·Seminars in Cardiothoracic and Vascular Anesthesia·Craig M McRobbMark D Twite
Dec 17, 2010·World Journal of Cardiology·Yves Durandy
Dec 24, 2010·World Journal of Cardiology·Yves Durandy
Nov 1, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Mirela BojanPascal Vouhé
Dec 6, 2018·Journal of Clinical Medicine·Vladimir MilovanovicSlobodan Ilic
Dec 30, 2020·Pediatric Cardiology·Melinda BarkhuizenAntonio W D Gavilanes
Mar 3, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dominic ZanaboniJoshua J Blinder
Jun 4, 2010·Anesthesia and Analgesia·Heather G YurkaUNKNOWN Congenital Heart Surgery Research Interest Group

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