PMID: 15381868Sep 24, 2004Paper

188Re-SSS lipiodol: radiolabelling and biodistribution following injection into the hepatic artery of rats bearing hepatoma

Nuclear Medicine Communications
Etienne GarinJean-Jacques Lejeune

Abstract

Although intra-arterial radiation therapy with 131I-lipiodol is a useful therapeutic approach to the treatment of hepatocellular carcinoma, various disadvantages limit its use. To describe the development of a method for the labelling of lipiodol with 188Re-SSS (188Re (S2CPh)(S3CPh)2 complex) and to investigate its biodistribution after injection into the hepatic artery of rats with hepatoma. 188Re-SSS lipiodol was obtained after dissolving a chelating agent, previously labelled with 188Re, in cold lipiodol. The radiochemical purity (RCP) of labelling was checked immediately. The 188Re-SSS lipiodol was injected into the hepatic artery of nine rats with a Novikoff hepatoma. They were sacrificed 1, 24 and 48 h after injection, and used for ex vivo counting. Labelling of 188Re-SSS lipiodol was achieved with a yield of 97.3+/-2.1%. The immediate RCP was 94.1+/-1.7%. Ex vivo counting confirmed a predominantly hepatic uptake, with a good tumoral retention of 188Re-SSS lipiodol, a weak pulmonary uptake and a very faint digestive uptake. The 'tumour/non-tumoral liver' ratio was high at 1, 24 and 48 h after injection (2.9+/-1.5, 4.1+/-/4.1 and 4.1+/-0.7, respectively). Using the method described here, 188Re-SSS lipiodol can be obtained ...Continue Reading

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Citations

Apr 24, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Mei TianSanjay Gupta
Mar 13, 2013·Annals of Nuclear Medicine·Ping-Wun HuangWan-Yu Lin
Apr 21, 2012·International Journal of Molecular Imaging·Nicolas LepareurEtienne Garin
May 9, 2013·International Journal of Molecular Imaging·Maria ArgyrouMaria Lyra
Jun 11, 2005·Journal of Vascular and Interventional Radiology : JVIR·Etienne GarinJean-Jacques Lejeune
Feb 15, 2011·Nuclear Medicine and Biology·Licia UccelliAdriano Duatti
Nov 18, 2005·International Journal of Radiation Oncology, Biology, Physics·Jean-Luc RaoulEtienne Garin
Nov 26, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Nicolas LepareurEtienne Garin
Jan 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Jean-Luc RaoulEtienne Garin
Aug 12, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Nicolas LepareurGiuliano Bandoli

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