18F-2-fluoro-2-deoxy-D-glucose positron emission tomography scanning affects surgical management in selected patients with high-risk, operable breast carcinoma

Annals of Surgical Oncology
Elisa Rush PortSteven M Larson

Abstract

The role of positron emission tomography (PET) scanning in determining the extent of disease in patients with breast cancer has not been defined. We investigated the utility of (18)F-2-fluoro-2-deoxy-D: -glucose (FDG)-PET scanning compared with conventional imaging with computed tomographic scanning and bone scanning in determining the extent of disease in patients with high-risk, operable breast cancer. This was a prospective study of patients who presented to Memorial Sloan-Kettering Cancer Center for operative treatment of breast cancer. Eighty eligible patients were enrolled and underwent computed tomographic chest, abdomen, pelvis, and bone scans, followed by FDG-PET. Changes in treatment based on scan findings were recorded by the operating surgeons. Imaging findings were verified by biopsy or long-term follow-up. Eight (10%) of 80 patients were found to have metastatic disease that was seen on both conventional imaging and PET. Four additional patients (5%) had additional foci of disease on PET that affected treatment decisions. No patient had findings on conventional imaging alone. Conventional imaging studies resulted in a higher number of findings that generated additional tests and biopsies that ultimately had negati...Continue Reading

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Citations

Sep 17, 2008·Radiation Oncology·Nidhi SharmaRoger Macklis
May 19, 2009·European Journal of Nuclear Medicine and Molecular Imaging·David GroheuxJean-Luc Moretti
Feb 18, 2010·Annals of Surgical Oncology·Alice ChungElisa Port
Nov 12, 2013·The Breast : Official Journal of the European Society of Mastology·Valentina RossiFilippo Montemurro
Mar 22, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S MahnerJ Dose-Schwarz
Feb 23, 2008·Connective Tissue Research·Ida Pucci-MinafraSalvatore Minafra
Feb 22, 2012·Journal of the American College of Surgeons·Quyen D ChuBenjamin D L Li
Sep 23, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z GaramiL Galuska
Apr 26, 2008·International Journal of Radiation Oncology, Biology, Physics·David GroheuxJean-Louis Misset
Dec 13, 2006·Radiologic Clinics of North America·Lia BartellaLaura Liberman
Aug 13, 2009·The Breast Journal·Matthew PuglieseClaire Buchanan
Jul 24, 2007·The Annals of Thoracic Surgery·Jeffrey L PortNasser K Altorki
Jun 13, 2013·The Breast : Official Journal of the European Society of Mastology·Masahiro OharaMorihito Okada
Jul 10, 2010·The Lancet Oncology·Einat Even-Sapir, Moshe Inbar
Jan 1, 2007·Proteomics. Clinical Applications·Ida Pucci-MinafraAntonio Marrazzo
Mar 12, 2009·Medical Oncology·S EscalonaN Gómez
Apr 28, 2012·The Oncologist·Ashley M GrovesMohammed R Keshtgar
Mar 13, 2013·Expert Review of Anticancer Therapy·Robert GoldsteinTim Meyer
Nov 22, 2012·Experimental and Therapeutic Medicine·Bengul GunalpEngin Alagoz
Mar 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph R OsborneSteven Larson

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