18F-fallypride binding potential in patients with schizophrenia compared to healthy controls.

Schizophrenia Research
Douglas S LehrerMonte S Buchsbaum

Abstract

Molecular imaging of dopaminergic parameters has contributed to the dopamine hypothesis of schizophrenia, expanding our understanding of pathophysiology, clinical phenomenology and treatment. Our aim in this study was to compare (18)F-fallypride binding potential BP(ND) in a group of patients with schizophrenia-spectrum illness vs. controls, with a particular focus on the cortex and thalamus. We acquired (18)F-fallypride positron emission tomography images on 33 patients with schizophrenia spectrum disorder (28 with schizophrenia; 5 with schizoaffective disorder) and 18 normal controls. Twenty-four patients were absolutely neuroleptic naïve and nine were previously medicated, although only four had a lifetime neuroleptic exposure of greater than two weeks. Parametric images of (18)F-fallypride BP(ND) were calculated to compare binding across subjects. Decreased BP(ND) was observed in the medial dorsal nucleus of the thalamus, prefrontal cortex, lateral temporal lobe and primary auditory cortex. These findings were most marked in subjects who had never previously received medication. The regions with decreased BP(ND) tend to match brain regions previously reported to show alterations in metabolic activity and blood flow and area...Continue Reading

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Citations

Jul 17, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Joseph KambeitzOliver D Howes
May 22, 2016·Biological Psychiatry·Jodi J WeinsteinAnissa Abi-Dargham
Jul 18, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Douglas S LehrerCarlos N Pato
Jul 23, 2014·Molecular Psychiatry·R S Kahn, I E Sommer
Dec 9, 2017·International Review of Psychiatry·Christin SchifaniRomina Mizrahi
Sep 26, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Serge A MitelmanDouglas S Lehrer
Jan 5, 2011·CNS Neuroscience & Therapeutics·Jussi Hirvonen, Jarmo Hietala

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