¹⁸F-FAMT uptake correlates with tumor proliferative activity in oral squamous cell carcinoma: comparative study with ¹⁸F-FDG PET and immunohistochemistry

Annals of Nuclear Medicine
Go MiyashitaKeigo Endo

Abstract

L-3-[¹⁸F]-fluoro-α-methyl tyrosine (FAMT) is transported into cancer cells by L: -type amino acid transporter 1 (LAT1). The purpose of the present study is to correlate the uptake of FAMT and FDG with the cellular proliferative activity measured by the Ki-67 labeling index (Ki-67 LI) in oral squamous cell carcinoma (OSCC). Twenty-five patients with OSCC were enrolled in this study. Both FAMT-PET and FDG-PET were performed within 4 weeks before surgery in all cases. The uptake of FAMT and FDG was compared by semiquantitative analysis with maximal standardized uptake values (SUVmax) of the primary tumors. Ki-67 LI of the tumors was analyzed by immunohistochemical staining and correlated with the clinicopathologic variables and the uptake of PET tracers. For primary tumor detection, FAMT-PET exhibited a sensitivity of 84%, whereas that of FDG-PET was 88%. In all visible lesions, mean FDG uptake determined by average SUVmax was 9.7 (range 4.2-15.9) and mean FAMT uptake was 3.5 (range 1.3-8.5). The SUVmax of FAMT tended to show a better correlation with Ki-67 LI (r = 0.878) than that of FDG (r = 0.643). Uptake of FAMT correlated with cellular proliferation of OSCC. FAMT-PET may be a useful procedure to evaluate tumor proliferation o...Continue Reading

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Citations

Dec 14, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Delphine DenoyerRodney J Hicks
Jun 27, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Aiko NobusawaTetsunari Oyama
Sep 6, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Motoho MoritaYoshito Tsushima
Aug 21, 2012·Annals of Nuclear Medicine·Atsushi IsodaYoshito Tsushima
Oct 2, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Shinji KitoYasuhiro Morimoto
Oct 1, 2012·PET Clinics·Tony J C WangNancy Y Lee
Dec 17, 2015·Intractable & Rare Diseases Research·Yu ZhaoJihong Pan
Mar 6, 2015·Acta Oto-laryngologica·Yuki YokoboriKazuaki Chikamatsu
Mar 30, 2020·Journal of Labelled Compounds & Radiopharmaceuticals·Aiko YamaguchiYoshito Tsushima
Dec 6, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mai KimYoshito Tsushima

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