(18)F-FDG dynamic PET/CT in patients with multiple myeloma: patterns of tracer uptake and correlation with bone marrow plasma cell infiltration rate

Clinical Nuclear Medicine
Christos SachpekidisAntonia Dimitrakopoulou-Strauss

Abstract

The value of F-FDG PET in the diagnostic approach of multiple myeloma (MM) remains incompletely elicited. Little is known about the kinetics of F-FDG in the bone marrow and extramedullary sites in MM. This study aimed to evaluate quantitative data on kinetics and distribution patterns of F-FDG in MM patients with regard to pelvic bone marrow plasma cell infiltration. The study included 40 patients with primary MM. Dynamic PET/CT scanning of the lower lumbar spine and pelvis was performed after the administration of F-FDG. Whole-body PET/CT studies were performed. Sites of focal increased tracer uptake were considered as highly suggestive of myelomatous involvement after taking into account the patient history and CT findings. Bone marrow of the os ilium without pathologic tracer accumulation served as reference. The evaluation of dynamic PET/CT studies was based in addition to the conventional visual (qualitative) assessment, on semiquantitative (SUV) calculations, as well as on absolute quantitative estimations after application of a 2-tissue compartment model and a noncompartmental approach. F-FDG quantitative information and corresponding distribution patterns were correlated with pelvic bone marrow plasma cell infiltration....Continue Reading

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Citations

Dec 6, 2018·Clinical Nuclear Medicine·Zhanli FuQian Li
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Evangelos TerposLia A Moulopoulos
Nov 13, 2015·Clinical Nuclear Medicine·Aiping ChengJigang Yang
Aug 31, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Christos SachpekidisA Dimitrakopoulou-Strauss
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Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
May 28, 2020·Cancers·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Jun 7, 2018·Cancer Immunology, Immunotherapy : CII·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
May 1, 2021·Diagnostics·Christos SachpekidisAntonia Dimitrakopoulou-Strauss
Jul 18, 2021·Seminars in Nuclear Medicine·Patrick PilkingtonKen Herrmann
Oct 11, 2021·EJNMMI Research·Christos SachpekidisAntonia Dimitrakopoulou-Strauss

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