(18)F-FDG PET-CT for Surveillance of Brazilian Patients with Li-Fraumeni Syndrome

Frontiers in Oncology
Sonia Tereza Santos NogueiraMaria Isabel Waddington Achatz

Abstract

To evaluate the effectiveness of (18)F-Fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) for detecting early cancer in carriers of germline TP53 mutation, the genetic defect underlying Li-Fraumeni and related syndromes, which predisposes to many forms of cancer throughout life. A total of 30 adult patients from six families with germline TP53 mutations were recruited. These patients did not have a diagnosis of cancer in the 24 months preceding the study. Anomalous concentrations from whole-body (18)F-FDG-PET/CT were assessed by two independent experts. Suspicious lesions were excised and subjected to pathological examination. A total of 6/30 patients showed abnormal (18)F-FDG-concentration. Confirmation studies revealed three cases of cancer, including one lung cancer, one ovarian cancer, and one disseminated breast cancer. Three patients had non-malignant lesions (one Bartholin's cyst and two cases of reactive lymph nodes). (18)F-FDG-PET/CT is effective in detecting cancer in subjects who are asymptomatic according to current screening guidelines. These results further suggest that (18)F-FDG-PET/CT is an appropriate method for surveillance of cancer risk in TP53 mutation carriers.

References

Oct 1, 1969·Annals of Internal Medicine·F P Li, J F Fraumeni
Jul 28, 2001·International Journal of Cancer. Journal International Du Cancer·J M LimacherJ P Bergerat
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Serena MasciariJudy E Garber
Aug 5, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie TinatThierry Frébourg
Sep 1, 2009·The Lancet Oncology·Maria Isabel Waddington AchatzPatricia Ashton-Prolla
Dec 3, 2009·Current Opinion in Oncology·Edenir I PalmeroPierre Hainaut

❮ Previous
Next ❯

Citations

Aug 2, 2016·Integrative Biology : Quantitative Biosciences From Nano to Macro·Laura AndolfiMarco Lazzarino
Aug 16, 2018·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Daniele PaixãoMaria Isabel Achatz
Jun 3, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christian P KratzDavid Malkin
Mar 23, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Paluch-ShimonO Pagani
Oct 12, 2021·International Journal of Clinical Oncology·Tadashi KumamotoYukiko Tsunematsu

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
biopsies

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.