18F-FDG PET with or without CT in the diagnosis of extrahepatic metastases or local residual/recurrent hepatocellular carcinoma

Medicine
Xiaoli LiaoChangyuan Wei

Abstract

The aim of the present study was to meta-analyze the literature on the diagnostic value of 18-fluorodeoxyglucose (F-FDG) positron emission tomography (PET) with or without computed tomography (CT) in detecting extrahepatic metastases or local residual/recurrent hepatocellular carcinoma (HCC).Systematic review of literature in MEDLINE, Embase, and Cochrane databases was conducted in March 2017, and relevant studies analyzing the diagnostic performance of F-FDG PET with or without CT were meta-analyzed.Meta-analysis was carried out on data from 11 studies involving 572 patients. F-FDG PET, with or without CT, showed pooled sensitivity of 64% and pooled specificity of 95%. Pooled sensitivity was similar with CT (74%) or without (52%; P = .279). Similarly, pooled specificity was comparable with CT (93%) or without 95% (P = .481).F-FDG PET, with or without CT, shows relatively low sensitivity but high specificity for diagnosing extrahepatic metastases or local residual/recurrent HCC. Adding CT to F-FDG PET may improve diagnostic performance, but the available evidence suggests that the improvement is not statistically significant.

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Citations

Sep 19, 2019·World Journal of Gastroenterology : WJG·Ren-Cai LuShao-Bo Wang
Dec 4, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Yun ZhangGuo-Kai Feng
Feb 7, 2020·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN INASL Task-Force on Hepatocellular Carcinoma
Mar 17, 2021·Nuclear Medicine and Biology·Ai-Mei LiMing Shi
Oct 2, 2021·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Samuel J GalganoJonathan E McConathy

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imaging techniques
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biopsy

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