18F-FDG PET/CT for Molecular Imaging of Hepatoblastoma in Beckwith-Wiedemann Syndrome

Clinical Nuclear Medicine
Thorsten DerlinKatja Hueper

Abstract

Beckwith-Wiedemann syndrome (BWS) is a rare congenital overgrowth disorder variably characterized by macrosomia, macroglossia, congenital hypoglycemia, and hemihyperplasia. The BWS predisposes affected individuals to embryonal tumors during childhood. The BWS is caused by abnormal gene regulation in a particular region of chromosome 11. We present the case of a 1-year-old boy with BWS who underwent an F-FDG PET/CT scan for restaging of hepatoblastoma. On the F-FDG PET scan, increased tracer accumulation was observed in hepatoblastoma lesions. In addition, marked hemihyperplasia was noted. This case highlights the usefulness of F-FDG PET/CT for restaging of hepatoblastoma in BWS.

References

May 12, 2005·American Journal of Medical Genetics. Part a·P RumpA J van Essen
Jul 7, 2005·European Journal of Human Genetics : EJHG·Wendy N CooperEamonn R Maher
Feb 17, 2007·Human Pathology·P DelonlayF Jaubert
Dec 10, 2013·Journal of Pediatric Surgery·Pablo LajeN Scott Adzick
Jan 13, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Lebriz UsluHeike E Daldrup-Link
Apr 23, 2015·European Journal of Human Genetics : EJHG·Alessandro MussaGiovanni Battista Ferrero
Aug 15, 2017·Clinical Nuclear Medicine·Bing ZhangXiangsong Zhang

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Citations

Mar 21, 2021·Nuclear Medicine Communications·Erika OritaMartin W Huellner

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Beckwith-Wiedemann syndrome is an imprinting disorder characterized by overgrowth, congenital malformations and predisposition to tumors. Discover the latest research on Beckwith-Wiedemann Syndrome here.