18F-FDG PET/CT in patients with amyloid light-chain amyloidosis: case-series and literature review

Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis
Arsene MekinianCentre de Référence des Amyloses immunoglobulinémiques et autres maladies liées aux dépots des immunoglobulines monoclonales

Abstract

To describe FDG-PET/CT in amyloid light-chain (AL) amyloidosis. We describe a French multicenter study which included patients with AL amyloidosis who had undergone a FDG-PET/CT during follow-up. Ten patients with AL amyloidosis (median age 62 years [59-85]) were analyzed. AL amyloidosis was of λ-type in 7/10 cases (70%) and localized amyloidosis in 4/10 cases (40%). AL amyloidosis was primary in 7/10 (70%) cases and associated with Waldenstrom's macroglobulinemia (n = 2) and plasmocytoma (n = 1) in the remaining cases. Median delay between diagnosis and PET was 1 month [0-51]. PET was positive in seven (70%) patients and showed a median FDG SUV of 6.5 [ 4-15 ]. FDG uptakes with positive PET were localized in seven patients, namely in the nasopharynx (n = 3), bronchopulmonary (n = 2), duodenal, cutaneous, bone, joint and muscular areas (n = 1, each). FDG uptakes on PET were concordant with the known organ impairment in 6/7 cases (86%) and showed unknown nasopharyngeal and mesenteric localization in one case each. PET was negative in the patient with cardiac amyloidosis and two patients with pulmonary amyloidosis. High FDG uptake may be present in patients with AL amyloidosis, however prospective studies are needed in order to d...Continue Reading

References

Mar 22, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M B Pepys
Oct 24, 2002·Current Opinion in Nephrology and Hypertension·Philip N Hawkins
Sep 15, 2004·Clinical Nuclear Medicine·Glenn P OllenbergerAndrew J Tauro
May 14, 2005·Clinical Nuclear Medicine·Ahuva GrubsteinMordechai R Kramer
Jun 11, 2005·Respiratory Medicine·Graeme P CurrieJoe S Legge
Oct 6, 2006·Journal of Cardiothoracic Surgery·Sumit YadavIan Gilfillan
Jan 24, 2008·AJR. American Journal of Roentgenology·Gethin Williams, Gerald M Kolodny
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Akihiko YoshidaHeiko Schöder
Jun 24, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rumman LangahLeonie Gordon
Oct 6, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Félicie CostantinoIsabelle Chary-Valckenaere
Dec 22, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ji Hyoung SeoJaetae Lee
Feb 23, 2010·Clinical Nuclear Medicine·Haibo TanXiangtong Lin
May 27, 2010·World Journal of Gastroenterology : WJG·Pier-Paolo MainentiMarco Salvatore
Dec 16, 2010·Clinical Nuclear Medicine·Arsene MekinianOlivier Fain
Jul 1, 2011·Clinical Nuclear Medicine·Michael SoussanPierre Weinmann
Sep 20, 2011·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Youn Mi SonByung-Tae Kim

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Citations

Mar 12, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Andor W J M GlaudemansBouke P C Hazenberg
Oct 29, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sabahat BokhariMathew S Maurer
Jul 31, 2013·British Medical Bulletin·Sajitha Sachchithanantham, Ashutosh D Wechalekar
Jul 18, 2014·PET Clinics·Jason W Wachsmann, Victor H Gerbaudo
Jul 8, 2015·Chest·Shraddha NarechaniaAdriano R Tonelli
Oct 1, 2013·Insights Into Imaging·Rahul D Renapurkar, Jeffrey P Kanne
Sep 15, 2014·Clinical and Experimental Medicine·Franco DammaccoVito Racanelli
Aug 19, 2015·Nuclear Medicine and Molecular Imaging·Joo Hee LeeJoon Young Choi
Mar 2, 2013·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Walter NoordzijBouke P C Hazenberg
Oct 29, 2014·Intestinal research·Jong Hyo ChoiMoon Sung Lee
May 20, 2016·Case Reports in Genetics·Abhisek SwaikaSikander Ailawadhi
Nov 27, 2014·Heart Failure Reviews·Walter NoordzijClaudio Rapezzi
Jul 30, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Miriam A Stats, James R Stone
Nov 5, 2016·QJM : Monthly Journal of the Association of Physicians·J BertolinoB Granel
Nov 2, 2016·Clinical Nuclear Medicine·Fuqiang ShaoYue Chen
Mar 31, 2017·Current Cardiovascular Imaging Reports·Malte Kircher, Constantin Lapa
Jul 25, 2014·JRSM Open·Rosie CresnerAshutosh D Wechalekar
Sep 15, 2017·Respiration; International Review of Thoracic Diseases·Yurdagül UzunhanDominique Valeyre
Mar 1, 2019·Current Cardiology Reports·Matthieu Pelletier-GalarneauFrancois Harel
Sep 10, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Riemer H J A SlartWalter Noordzij
Apr 6, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Aida Sabaté-LloberaCristina Gámez-Cenzano
Nov 13, 2018·Case Reports in Hematology·Sebastiano CiccoVito Racanelli
Jan 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Masatoshi HottaHiroyuki Yamashita
Feb 25, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Malte KircherConstantin Lapa
Oct 22, 2020·Current Medical Imaging·Viviana FrantellizziGiuseppe De Vincentis
May 18, 2021·Leukemia Research Reports·Eli MuchtarMorie A Gertz
Sep 12, 2020·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Alexios S AntonopoulosFrancisco Alpendurada

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