18F-FDG PET/CT in the post-operative monitoring of patients with adrenocortical carcinoma

European Journal of Endocrinology
A ArditoM Terzolo

Abstract

The role of (18)F-labeled 2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET)/computed tomography (CT) in the post-operative monitoring of patients with adrenocortical carcinoma (ACC) is still unclear. To assess the accuracy of FDG PET/CT to diagnose ACC recurrence in a real world setting. Retrospective evaluation of data of 57 patients with presumed ACC recurrence at CT scan who underwent FDG PET/CT within a median time of 20 days. We compared the results of either FDG PET/CT or CT with a gold standard confirmation of recurrence (positive histopathology report of removed/biopsied lesions or radiological progression of target lesions at follow-up) to assess their diagnostic performance at different body sites to correctly categorize target lesions. We also assessed whether FDG PET/CT findings may be useful to inform the management strategy. In 48 patients with confirmed ACC recurrence, we found that FDG PET/CT had lower sensitivity than CT in diagnosing liver and lung recurrences of ACC. FDG PET/CT had higher specificity than CT in categorizing liver lesions. FDG PET/CT had a greater positive likelihood ratio than CT to identify liver and abdominal ACC recurrences. The management strategy was changed based on FD...Continue Reading

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Citations

Jan 19, 2018·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Abdul RazikSanjay Sharma
May 26, 2016·Japanese Journal of Radiology·Kazuhiro KitajimaHossein Jadvar

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