18F-FDG PET/CT of Non-Small Cell Lung Carcinoma Under Neoadjuvant Chemotherapy: Background-Based Adaptive-Volume Metrics Outperform TLG and MTV in Predicting Histopathologic Response

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Irene A BurgerAlex Soltermann

Abstract

Assessment of tumor response after chemotherapy using (18)F-FDG PET metrics is gaining acceptance. Several studies have suggested that the parameters metabolically active tumor volume (MTV) and total lesion glycolysis (TLG) are superior to SUVmax for measuring tumor burden. However, the measurement of MTV and TLG is still controversial; the most common method uses an absolute threshold of 42% of SUVmax Recently, we implemented a background-adaptive method to determine the background-subtracted lesion activity (BSL) and the background-subtracted volume (BSV). In this study, we investigated the correlation between such PET metrics and histopathologic response in non-small cell lung carcinoma (NSCLC). Forty-four NSCLC patients were retrospectively identified. Their PET/CT data on both types of scan before and after neoadjuvant chemotherapy were analyzed regarding SUVmax, MTV, TLG, BSL, and BSV, as well as the relative changes in these parameters. The tumor regression score as an indicator of histopathologic response was scored on hematoxylin- and eosin-stained sections of the surgical specimens using a 4-tiered scale (scores 1-4). The correlation between score and the absolute and relative PET metrics after chemotherapy was analyz...Continue Reading

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Citations

Dec 16, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Osamu ManabeNagara Tamaki
Feb 3, 2018·Nuclear Medicine and Molecular Imaging·Hyung-Jun ImSteve Y Cho
May 29, 2019·Nuclear Medicine Communications·Natale QuartuccioUNKNOWN Young AIMN Working Group
Jul 17, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ruben CasanovaAlex Soltermann
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Dec 8, 2019·Journal of Nuclear Medicine Technology·Ismet Sarikaya, Ali Sarikaya
Jul 6, 2021·Frontiers in Oncology·Hongwei SiSijin Li
Dec 31, 2019·Current Radiopharmaceuticals·Angelo CastelloEgesta Lopci

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