18F-FDG PET/CT: Therapy Response Assessment Interpretation (Hopkins Criteria) and Survival Outcomes in Lung Cancer Patients

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Sara SheikhbahaeiRathan M Subramaniam

Abstract

The purpose of this study was to evaluate the value of an (18)F-FDG PET/CT-based interpretation system (Hopkins criteria) to assess the therapy response and survival in lung cancer. This is an Institutional Review Board-approved, retrospective study. A total of 201 patients with biopsy-proven lung cancer, who underwent therapy assessment (18)F-FDG PET/CT within 6 mo (mean, 7.5 wk) of completion of treatment, were included. Patients were primarily treated with surgical resection, chemotherapy, radiation therapy, or a combination of these treatments. PET/CT studies were interpreted by 2 nuclear medicine physicians, and discrepancies were resolved by a third interpreter. The studies were scored using a qualitative 5-point scale for the primary tumor, mediastinum, distant metastatic site, if present, and overall assessment. Scores 1, 2, and 3 were considered negative and scores 4 and 5 were considered positive for residual disease. Patients were followed for a median of 12 mo (up to 128 mo). Kaplan-Meier plots with a Mantel-Cox log-rank test were performed considering death as the endpoint. Overall, the PET/CT studies were positive in 144 (71.6%) and negative in 57 (28.4%) patients. There was substantial agreement between 2 interpr...Continue Reading

References

Jun 28, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G MikhaeelA R Timothy
Jan 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D ChesonUNKNOWN International Harmonization Project on Lymphoma
Apr 7, 2007·Journal of the American College of Radiology : JACR·Mylene T TruongBenjamin Movsas
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Jul 3, 2009·The New England Journal of Medicine·Barbara FischerLiselotte Højgaard
Apr 5, 2011·European Journal of Radiology·Valentina AmbrosiniStefano Fanti
Jul 19, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Edwin A UsmanijJohan Bussink
Aug 27, 2013·Lancet·Martin ReckKlaus F Rabe
Oct 9, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Vasavi PaidpallyRathan M Subramaniam
Apr 30, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alexander J AntoniouRathan M Subramaniam
Jun 21, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Charles MarcusRathan M Subramaniam
Jan 16, 2015·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Ameya D PuranikVenkatesh Rangarajan
Mar 6, 2015·Clinical Nuclear Medicine·Ercan KurtipekTaha Tahir Bekci
Apr 29, 2015·Nature Reviews. Clinical Oncology·Willem GrootjansJohan Bussink
May 6, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hao ZhangYonglin Pu
Jul 17, 2015·JAMA Oncology·UNKNOWN Global Burden of Disease Cancer CollaborationMohsen Naghavi

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Citations

Oct 12, 2016·AJR. American Journal of Roentgenology·Sara SheikhbahaeiRathan M Subramaniam
May 11, 2017·Nuclear Medicine Communications·Eric LaffonRoger Marthan
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lou ZhongZhong Chen
Apr 30, 2017·European Journal of Nuclear Medicine and Molecular Imaging·C M DerooseP Bourguet
Jun 20, 2020·AJR. American Journal of Roentgenology·Kevin P BanksMichael N Clemenshaw
Apr 3, 2020·Physics in Medicine and Biology·Kevin H LeungAbhinav K Jha
Nov 5, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mehdi TaghipourRathan M Subramaniam
Jul 22, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Guy-Anne TurgeonMichael P Mac Manus
Dec 31, 2019·Current Radiopharmaceuticals·Angelo CastelloEgesta Lopci
Nov 5, 2021·Clinical Nuclear Medicine·Hai-Jeon Yoon, Kyoungjune Pak

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