(18)F-FDG uptake on PET correlates with biological potential in early oral squamous cell carcinoma

Acta Oto-laryngologica
Yuki YokoboriKazuaki Chikamatsu

Abstract

The maximum standardized uptake value (SUVmax) of early oral squamous cell carcinoma (OSCC) may have a role as an imaging biomarker for assessment of malignant potential, including cell metabolism and angiogenesis. The usefulness of (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) has been proven in various cancers, including OSCC. Moreover, in several carcinomas, the SUVmax of the tumor has been shown to correlate with the histological type, tumor stage, differentiation, and prognosis. Here, we investigated whether the SUVmax of early OSCC was associated with the biological features. Twenty-seven patients with newly diagnosed early OSCC who underwent preoperative FDG-PET and curative surgical resection were included in this study. Tumor sections were stained by immunohistochemistry for glucose transporter 1 (GLUT1), L-type amino acid transporter 1 (LAT1), CD98, microvessels (CD34), cell proliferation marker (Ki-67), and cell cycle regulator (p53). The correlation between SUVmax and clinicopathological findings or the expression level of these molecules was analyzed. SUVmax of primary OSCC was significantly higher in patients with T2 stage. Moreover, patients whose tumors showed vascular invasion had a tendency t...Continue Reading

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Citations

May 28, 2016·Cell Cycle·Susana Simões-SousaFatima Baltazar
Jun 23, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Alexey SurovSandra Purz
Aug 28, 2021·Biomolecules·Heinrich BothaAntonio Celentano

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