Abstract
Histopathological examination is the standard for grading and determination of diagnosis in intrinsic brain tumors though the possibility of malignization and tumor heterogeneity always bears the possibility of tumor under-grading or misjudgement regarding the estimation of prognosis. The aim of the present study was to evaluate the use of (18)F-FET-PET (FET-PET) for the grading and estimation of prognosis in newly diagnosed patients with intracranial gliomas in a clinical setting. Patients who were treated for a newly diagnosed intracranial glioma between January 2007 and May 2012, and had a preoperative FET-PET and MRI scan between were included. The ratio of counts in a tumor VOI (volume of interest) with maximum uptake to the respective counts in a background VOI was calculated to provide the tumor-to-normal (T/N) ratio. The clinical and histopathological data (tumor grading, pre- and postoperative neurological status, Karnofsky Performance Status Scale scores, and overall survival rates) were recorded. One hundred fifty-two patients (39 WHO II, 26 WHO III, 87 WHO IV) were included. The median T/N ratio was 2.81 (1.1-8.1). The median T/N ratio of low-grade glioma patients was 1.65 (1.1-3.7), and 3.14 (1.61-8.1, p<0.001) in ...Continue Reading
References
Sep 21, 2001·Neurosurgery·D CroteauT Mikkelsen
Sep 26, 2002·Neurology·J N ScottP A Forsyth
Jun 21, 2003·Journal of Neurosurgery·Christoph BurkhardHiroko Ohgaki
Sep 8, 2005·Neurosurgery·Walter RachingerJörg-Christian Tonn
Apr 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Frank W FloethKarl-Josef Langen
Apr 26, 2007·The American Journal of Pathology·Hiroko Ohgaki, Paul Kleihues
May 17, 2007·Neuro-oncology·John K WienckeDavid Stokoe
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 4, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Gabriele PöpperlKlaus Tatsch
Aug 1, 2008·Neuro-oncology·Uwe PichlmeierUNKNOWN ALA Glioma Study Group
Mar 10, 2009·Acta Neuropathologica·Kathleen M TibbettsJeffrey Russell Leonard
Sep 1, 2009·Physics in Medicine and Biology·Frank ThieleChristian Boy
Feb 23, 2010·Seminars in Roentgenology·Sahil SoodApostolos J Tsiouris
Jun 4, 2010·European Radiology·Michail PlotkinF Stockhammer
Oct 26, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Georg WidhalmStefan Wolfsberger
Dec 29, 2010·Annals of Nuclear Medicine·Shozo OkamotoNagara Tamaki
May 17, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elena PrietoJavier Arbizu
May 31, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Markus HuttererGuenther Stockhammer
Jul 16, 2011·Neuro-oncology·Christian la FougèreJörg-Christian Tonn
Jan 24, 2012·AJNR. American Journal of Neuroradiology·L KhalidD M Yousem
Dec 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marion RappKarl-Josef Langen
May 21, 2013·European Radiology·Max-Ludwig SchäferEdzard Wiener
Jul 11, 2013·European Radiology·Roberto Sanz-RequenaGracián García-Martí
Jan 1, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Nathalie L JansenChristian la Fougère
Citations
Aug 10, 2015·World Neurosurgery·Jens GemptFlorian Ringel
Feb 9, 2016·World Neurosurgery·Stefanie BetteFlorian Ringel
Mar 8, 2016·World Neurosurgery·Stefanie BetteJens Gempt
Aug 6, 2015·Neuro-oncology·Vincent DunetJohn O Prior
Nov 11, 2017·Future Oncology·Syed O Mahboob, Muftah Eljamel
Oct 12, 2018·Nuclear Medicine Communications·Nina M MansoorFrancesco Fraioli
Dec 19, 2018·Cancer Medicine·Jan C PeekenStephanie E Combs
Jul 10, 2020·Cancer Biotherapy & Radiopharmaceuticals·Nisha RaniAnil K Mishra
Aug 12, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W-D Heiss
Sep 14, 2019·World Journal of Nuclear Medicine·Ameya D PuranikSneha Shah
Jul 12, 2018·Journal of Neuro-oncology·Christian F FreyschlagEmmanuel Mandonnet
Dec 21, 2016·Clinical Pharmacokinetics·Peggy GandiaDidier Concordet
Aug 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Manuel RöhrichUwe Haberkorn
Feb 1, 2020·Medicine·Gurvan DissauxSolène Querellou
Sep 1, 2021·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A Yu BelyaevA I Batalov