18F-fluoro-ethyl-tyrosine positron emission tomography for grading and estimation of prognosis in patients with intracranial gliomas

European Journal of Radiology
Jens GemptFlorian Ringel

Abstract

Histopathological examination is the standard for grading and determination of diagnosis in intrinsic brain tumors though the possibility of malignization and tumor heterogeneity always bears the possibility of tumor under-grading or misjudgement regarding the estimation of prognosis. The aim of the present study was to evaluate the use of (18)F-FET-PET (FET-PET) for the grading and estimation of prognosis in newly diagnosed patients with intracranial gliomas in a clinical setting. Patients who were treated for a newly diagnosed intracranial glioma between January 2007 and May 2012, and had a preoperative FET-PET and MRI scan between were included. The ratio of counts in a tumor VOI (volume of interest) with maximum uptake to the respective counts in a background VOI was calculated to provide the tumor-to-normal (T/N) ratio. The clinical and histopathological data (tumor grading, pre- and postoperative neurological status, Karnofsky Performance Status Scale scores, and overall survival rates) were recorded. One hundred fifty-two patients (39 WHO II, 26 WHO III, 87 WHO IV) were included. The median T/N ratio was 2.81 (1.1-8.1). The median T/N ratio of low-grade glioma patients was 1.65 (1.1-3.7), and 3.14 (1.61-8.1, p<0.001) in ...Continue Reading

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Citations

Aug 10, 2015·World Neurosurgery·Jens GemptFlorian Ringel
Mar 8, 2016·World Neurosurgery·Stefanie BetteJens Gempt
Oct 12, 2018·Nuclear Medicine Communications·Nina M MansoorFrancesco Fraioli
Aug 12, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W-D Heiss
Sep 14, 2019·World Journal of Nuclear Medicine·Ameya D PuranikSneha Shah
Jul 12, 2018·Journal of Neuro-oncology·Christian F FreyschlagEmmanuel Mandonnet
Aug 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Manuel RöhrichUwe Haberkorn
Feb 1, 2020·Medicine·Gurvan DissauxSolène Querellou
Sep 1, 2021·Zhurnal voprosy neĭrokhirurgii imeni N. N. Burdenko·A Yu BelyaevA I Batalov

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