18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer

Journal of Surgical Oncology
Daniel VallböhmerStefan P Mönig

Abstract

Neoadjuvant chemotherapy is applied to improve the prognosis of patients with advanced gastric cancer. However, only a major histopathological response will provide a benefit. Recent studies suggest that [(18)F]-fluorodeoxyglucose-positron-emission-tomography (FDG-PET) correlates with response and survival in patients with gastroesophageal adenocarcinomas undergoing neoadjuvant chemotherapy. We evaluated the potential of FDG-PET for the assessment of response and prognosis in the multimodality treatment of gastric cancer. Study patients were recruited from a prospective observation trial. Forty two patients with advanced gastric cancer received neoadjuvant chemotherapy and subsequently 40 patients underwent standardized gastrectomy (2 patients with tumor progression had therapy limited to palliative chemotherapy without surgery). Histomorphologic regression was defined as major response when resected specimens contained <10% vital tumor cells. FDG-PET was performed before and 2 weeks after the end of neoadjuvant chemotherapy with assessment of the intratumoral FDG-uptake [pre-treatment standardized uptake value (SUV1); post-treatment SUV (SUV2); percentage change (SUVDelta%)]. Histomorphological tumor regression was confirmed a...Continue Reading

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Citations

Feb 19, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaKoji Murakami
Nov 1, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L E FerriM P Thirlwell
Aug 7, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Stefan WiehrBernd J Pichler
May 28, 2011·International Journal of Cancer. Journal International Du Cancer·Nils HomannSalah-Eddin Al-Batran
Dec 30, 2014·World Journal of Surgical Oncology·Zhipeng Sun, Nengwei Zhang
Jun 19, 2015·Nuclear Medicine and Molecular Imaging·Hae Won KimYu Na Kang
Apr 9, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Young-Woo KimSook Ryun Park
Jun 12, 2012·The Journal of Surgical Research·Subhasis MisraLeonidas G Koniaris
Apr 12, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christina SchneiderMatthias C Schmidt
Nov 27, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chenchen WangJin Li

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