18F-Fluorodeoxyglucose positron-emission tomography (PET) can be used to assess inflammation non-invasively in Crohn's disease.

Digestive Diseases and Sciences
Martin H HoltmannMarkus F Neurath

Abstract

Differential therapy requires repeated diagnostic assessment for mapping and monitoring of disease activity in Crohn's disease (CD). The purpose of this prospective study was to evaluate the accuracy of (18)F-fluorodexyglucose positron-emission tomography (FDG-PET) for non-invasive assessment of disease activity in CD. Forty-three patients with CD underwent ileocolonoscopy and hydromagnetic resonance imaging (hydro-MRI) as reference standards. In addition, FDG-PET was performed and correlated with clinical data, hydro-MRI, and endoscopy findings. Diagnostic accuracy was determined for all methods. Two-hundred and forty-one bowel segments could be analyzed by all methods. Of 80 endoscopically inflamed segments in CD, FDG-PET detected 72 and hydro-MRI 53 segments. Overall sensitivity was 90 % (FDG-PET) versus 66 % (hydro-MRI), and specificity was 92.6 % versus 99 %. In the proximal ileum, hydro-MRI revealed inflammation in eight out of 49 patients and FDG-PET, also, detected all of these inflamed segments. Seventeen stenoses could be identified in 43 CD patients. With regard to assessment as inflammatory or fibrotic stenosis, there was good concordance between colonoscopy, hydro-MRI, and FDG-PET. In one case only, the nature of t...Continue Reading

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Citations

Nov 21, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Babak SabouryAbass Alavi
Nov 23, 2015·PET Clinics·Chandan J DasArun K Gupta
Nov 16, 2016·World Journal of Radiology·Federico Caobelli Young Aimn Working Group
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Dec 17, 2020·Nuklearmedizin. Nuclear Medicine·Stefanie PektorMatthias Miederer
Jul 20, 2021·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Massimiliano CasaliAlberto Signore

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