18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography in response evaluation after chemo-/radiotherapy of non-small-cell lung cancer: a feasibility study

BMC Cancer
Bernd GagelMichael J Eble

Abstract

Experimental and clinical evidence suggest that hypoxia in solid tumours reduces their sensitivity to conventional treatment modalities modulating response to ionizing radiation or chemotherapeutic agents. The aim of the present study was to show the feasibility of determining radiotherapeutically relevant hypoxia and early tumour response by ([18F] Fluoromisonidazole (FMISO) and [18F]-2-fluoro-2'-deoxyglucose (FDG) PET. Eight patients with non-small-cell lung cancer underwent PET scans. Tumour tissue oxygenation was measured with FMISO PET, whereas tumour glucose metabolism was measured with FDG PET. All PET studies were carried out with an ECAT EXACT 922/47 scanner with an axial field of view of 16.2 cm. FMISO PET consisted of one static scan of the relevant region, performed 180 min after intravenous administration of the tracer. The acquisition and reconstruction parameters were as follows: 30 min emission scanning and 4 min transmission scanning with 68-Ge/68-Ga rod sources. The patients were treated with chemotherapy, consisting of 2 cycles of gemcitabine (1200 mg/m2) and vinorelbine (30 mg/m2) followed by concurrent radio- (2.0 Gy/d; total dose 66.0 Gy) and chemotherapy with gemcitabine (300-500 mg/m2) every two weeks. F...Continue Reading

References

Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H MinnH Sipilä
Nov 1, 1990·Journal of Computer Assisted Tomography·Y NagataK Okajima
Nov 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J S RaseyK A Krohn
Mar 1, 1995·European Journal of Nuclear Medicine·A NunnH W Strauss
Mar 1, 1995·Archives of Otolaryngology--head & Neck Surgery·C ReisserL G Strauss
Sep 30, 1993·International Journal of Radiation Oncology, Biology, Physics·L ChaikenR Parker
Jan 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M HöckelP Vaupel
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Price, T Jones
Dec 20, 2002·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Peter VaupelMichael Höckel
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J DowneyValerie Rusch
Mar 26, 2003·International Journal of Radiation Oncology, Biology, Physics·Georg StübenPeter Vaupel
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael P Mac ManusDavid L Ball
Sep 27, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Jürgen DunstThomas Kuhnt
Sep 27, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Ulrich SchäferNormann Willich
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·J P KirkpatrickM W Dewhirst
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·C Clifton LingAndrew Jackson
Oct 14, 2004·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Bernd GagelMichael J Eble
Nov 5, 2005·European Journal of Nuclear Medicine and Molecular Imaging·S M EschmannR Bares
Apr 1, 2011·The Journal of Physical Chemistry. B·Brian C BohrerDavid E Clemmer

❮ Previous
Next ❯

Citations

Nov 1, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Michela LecchiGiovanni Lucignani
May 30, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Rudi Andre Dierckx, Christophe Van de Wiele
Aug 12, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ludwig DuboisLuc Mortelmans
Jul 1, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Gilles MeesChristophe Van de Wiele
Jun 4, 2010·European Journal of Nuclear Medicine and Molecular Imaging·George Laking, Pat Price
Apr 17, 2008·Cancer Metastasis Reviews·Aaron P BrownKevin A Camphausen
May 29, 2008·Cancer Metastasis Reviews·Rodolfo PeriniMark A Rosen
Sep 15, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Xilin SunXiaoyuan Chen
Mar 3, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Joshua MillerMatthew K Robinson
Aug 28, 2009·Expert Reviews in Molecular Medicine·Evon PoonMargaret Ashcroft
Jan 19, 2008·Nature Reviews. Cancer·Kevin Brindle
Apr 28, 2011·Nature Reviews. Clinical Oncology·Bruno Morgan
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ludwig J DuboisPhilippe Lambin
Jun 29, 2010·Cancer Biotherapy & Radiopharmaceuticals·Seyed K Imam
Nov 19, 2015·International Journal of Clinical Oncology·Nagara Tamaki, Kenji Hirata
Apr 20, 2012·Expert Opinion on Therapeutic Targets·Dylan T Jones, Adrian L Harris
Mar 29, 2014·Radiation Research·Olivia J Kelada, David J Carlson
Dec 17, 2014·British Journal of Cancer·I N FlemingF J Gilbert
Sep 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Catharina M L ZegersPhilippe Lambin
Oct 18, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xue MengJinming Yu
Nov 29, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anders E HansenSvend A Engelholm
Sep 8, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Roslyn FrancisLaurence Morandeau
Jan 19, 2016·Molecular Oncology·Elena Hernández-AgudoMiguel Quintela-Fandino
Jun 28, 2011·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Ting-Ting He, Jia-He Tian
Nov 14, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Dharmarajan SriramPerumal Yogeeswari
Dec 11, 2014·World Journal of Clinical Oncology·Eline E VerwerAstrid Am van der Veldt
Dec 1, 2006·Der Radiologe·A J Beer, M Schwaiger
Mar 21, 2008·International Journal of Cancer. Journal International Du Cancer·Morten BuskJens Overgaard
Feb 24, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Connie YipGary J R Cook
Mar 27, 2015·Radiology and Oncology·Stasa Jelercic, Mirjana Rajer
Jun 6, 2018·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Willem GrootjansJohan Bussink
Jun 10, 2017·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Amarnath ChallapalliEric O Aboagye
Sep 22, 2017·EJNMMI Research·Tanuj PuriTim Maughan
Mar 12, 2015·Technology in Cancer Research & Treatment·Nils D ArvoldUmar Mahmood
Jan 8, 2021·Journal of Translational Medicine·Violena Pietrobon, Francesco M Marincola
Feb 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ana Margarida AbrantesMaria Filomena Botelho
Apr 3, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Peter EbbesenAndrea Scozzafava

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.